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Respiratory > pain in the ass hypersensitivity > Flashcards

pain in the ass hypersensitivity Flashcards

1
Q

Type I

A

Immediate hypersensitivity

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2
Q

Type II

A

Direct cell killing

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3
Q

Type III

A

Immune complex mediated

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4
Q

Type IV

A

Delayed type hypersensitivity

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5
Q

Allergic disease

A

Type I hypersensitivity

IgE mediated

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6
Q

Contact dermatitis

A

Delayed type IV hypersensitivity

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7
Q

Investigations for allergy

A

Skin prick tests
Quantitate specific IgE to putative allergen
Challenge test (supervised exposure to putative antigen)

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8
Q

Test you could do DURING anaphylactic episode

A

Evidence of mast cell degranulation –> serum tryptase levels

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9
Q

Name a mast cell destabiliser

A

Sodium cromoglycate

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10
Q

Which receptors do anti-histamines block?

A

H1

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11
Q

Which receptors does anaphylaxis work on?

A

Acts on β2 adrenergic receptors to constrict arterial smooth muscle

Increases blood pressure thereby limiting vascular leakage
Dilates bronchial smooth muscle, thereby decreasing airflow obstruction

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12
Q

What is IPEX syndrome?

A

Immune dysfunction, polyendocrinopathy, enteropathy and X-linked inheritance syndrome

  • basically overwhelming systemic autoimmunity
  • severe infections
  • intractable diarrhoea
  • eczema
  • very early onset diabetes
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13
Q

Reactive arthritis more common if you have which HLA?

A

HLA-B27

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14
Q

Immune mediators in type I reactions

A

Mast cells

Eosinophils

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15
Q

Sarcoidosis hypersensitivity

A

Type IV

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16
Q

Farmers lung hypersensitivity

A

Type III

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17
Q

Immune haemolytic anaemia hypersensitivity

A

Type II

18
Q

Goodpasture’s syndrome

A

Type II

antibodies bind to glomerular basement membrane

19
Q

Grave’s disease

A

Type II

antibodies bind to epithelial cell cement

20
Q

Pemphigus vulgaris

A

Type II

antibodies bind to epithelial cell cement

21
Q

Myasthenia gravis

A

Type II

acetyl choline receptor

22
Q

Guillan Barre syndrome

A

Type II

(antibodies bung to peripheral nerve glycoprotein

23
Q

What to the antibodies bind to in Guillan Barre?

A

The peripheral nerve glycoprotein

24
Q

Type II hypersensitivity management

A

Plasmapheresis and immunosuppression

25
Q

SLE

A

Type III

26
Q

SLE antibodies

A

Anti-nuclear antigens

27
Q

Main Ig in placenta?

A

IgG plagenta

28
Q

Main Ig in breast milk?

A

IgA breAst milk

29
Q

Most common form of SCID?

A

X-linked SCID

  • mutation of IL-2 receptor
  • very low or absent T cells
  • normal or increased B cells
  • poorly developed lymphoid tissue and thymus
30
Q

Development defect of 3rd/4th pharyngeal pouch?

A

DiGeorge syndrome

31
Q

22q11

A

DiGeorge

32
Q

Investigations of B cell deficiencies

A

Total white cel count and differential

Serum/urine immunoglobulins

33
Q

Direct cell killing

A

Type II

34
Q

Immune complex mediated

A

Type III

35
Q

Delayed type hypersensitivity

A

Type IV

36
Q

Acute haemolytic transfusion reaction?

A

Type II

ABO incompatibility = lysis of donor erythrocytes by pre-formed recipient IgG antibodies

37
Q

Type I diabetes

A

Type IV

38
Q

Psoriasis

A

Type IV

39
Q

Rheumatoid arthritis

A

Type IV

40
Q

Tuberuclosis

A

Type IV

41
Q

Leprosy

A

Type IV

42
Q

Cellular rejection of solid organ transplant?

A

Type IV

Respiratory (13 decks)

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