Pain Characterization

Question 1

Carbamezepine

Answer 1

Trigeminal neuralgia and anti-convulsant.

Question 2

Gabapentin

Answer 2

Postherpetic neuralgia and anti-convulsant.

Question 3

Pregabalin

Answer 3

Post-herpetic neuralgia
Diabetic neuropathy
Fibromyalgia
Spinal cord injury

Question 4

Amitriptyline

Answer 4

Anti-depressant

Am I trippin’? No, you’re just depressed.

Question 5

Duloxetine

Answer 5

Diabetic neuropathy
Fibromyalgia
SNRI

Question 6

Lidocaine and Capsaicin

Answer 6

Post-herpetic neuralgia

Question 7

This type of pain is caused by injury to body tissues.

Answer 7

Nociceptive pain

Question 8

Most pain is _______.

Answer 8

Nociceptive

Question 9

This pain is caused by damage to the nervous system.

Answer 9

Neuropathic

Question 10

Pain receptors for tissue injury.

Answer 10

Nociceptors

Question 11

Chronic pain is ___________ in nature.

Answer 11

Neuropathic

Question 12

Most pain due to cancer us ____________.

Answer 12

Nociceptive

Question 13

“To do harm” in Italian

Answer 13

Nuocere

Question 14

Most chronic pain is neuropathic, except for these two things, which are nociceptive, but chronic in nature.

Answer 14

Osteoarthritis and Rheumatoid Arthritis

Question 15

3 Types of nociceptors

Answer 15

Thermal
Mechanical
Chemical

Question 16

Characteristic of dendrites on nociceptors.

Answer 16

NOT encapsulated

Question 17

These drugs are used to treat nociceptive pain.

Answer 17

Acetaminophen (Tylenol)
NSAIDs
Opioids

Question 18

This pain results from damage to the peripheral or central nervous system rather than stimulation of pain receptors.

Answer 18

Neuropathic pain

Question 19

A painful response to a stimulus that’s not painful.

Answer 19

Allodynia

Question 20

An exaggerated painful response to a painful stimulus.

Answer 20

Hyperalgesia

Question 21

This pain results from damage to or dysfunction of the peripheral or central nervous system, rather than stimulation of pain receptors.

Answer 21

Neuropathic pain

Question 22

Common causes of neuropathic pain: (these are all in blue).

Answer 22

Diabetic neuropathy
Postherpetic neuralgia
Facial nerve problems
MS
Chemotherapy
Amputation
HIV
Spine surgery
Alcoholism

Question 23

Two most common forms of neuropathic pain.

Answer 23

1) Postherpetic neuralgia (shingles).

2) Diabetic peripheral neuropathy

Question 24

Possible cause of trigeminal neuralgia.

Answer 24

Blood vessels compress CN V.

Question 25

These do not help treat trigeminal neuralgia.

Answer 25

Analgesics and opioids.

Question 26

First-line drug for Trigeminal Neuralgia

Answer 26

Anti-epileptic drugs Like Carbamazepine

Question 27

This drug is anti-epileptic and is used for partial pain relief for 80-90% of people with Trigeminal Neuralgia.

Answer 27

Carbamezepine

Question 28

These 3 drugs are used to treat Chronic Neuropathic pain:

Answer 28

1) Anticonvulsant drugs 2) Anti-depressants 3) Topical lidocaine or Topical Capsaicin

Question 29

Anticonvulsant drugs

Answer 29

Carbamezepine Gabapentin Pentagabalin

Question 30

Antidepressants

Answer 30

Amitriptyline Duloxetine

Question 31

Topical lido and capsaicin are used for ________.

Answer 31

Neuropathy

Question 32

Carbamezepine MOA

Answer 32

Inhibits Sodium channels on neurons, this reducing their excitability.

Question 33

The main inhibitory neurotransmitter in the CNS.

Answer 33

GABA

Question 34

What is Gabapentin used for?

Answer 34

Post-herpetic neuralgia and anti-convulsant.

Question 35

MOA of gabapentin and pregabalin.

Answer 35

Inhibit Calcium receptors, preventing the exocytosis of neurotransmitters.

Question 36

Used for the treatment of pain associated with diabetic neuropathy, postherpetic neuralgia, fibromyalgia, and neuropathic pain associated with spinal cord injury.

Answer 36

Pregabalin

Question 37

Used off-label in the treatment of trigeminal neuralgia.

Answer 37

Pregabalin

Question 38

Recommended by the Neuropathic Pain Group of the International Association for the Study of Pain (IASP) as first-line treatment for neuropathic pain.

Answer 38

Amitriptyline.

Question 39

How does Amitriptyline work?

Answer 39

Inhibits the reuptake of Serotonin and NE from the presynaptic nerve. Also blocks cholinergic, adrenergic, and histaminergic receptors and sodium channels.

Question 40

Anticholinergic side effects (like dry mouth and eyes, urinary retention, excess sedation, orthostatic hypotension, constipation, and blurry vision) occur with these drugs.

Answer 40

Tricyclic antidepressants - Amitriptyline.

Question 41

SNRI stands for:

Answer 41

Serotonin Norepinephrine reuptake inhibitor

Question 42

A SNRI antidepressant used for diabetic neuropathy and fibromyalgia (neuropathic pains).

Answer 42

Duloxetine

Question 43

Topical Lido MOA

Answer 43

Blocks voltage-gated Na channels.

Question 44

First line option to treat localized peripheral neuropathic pain.

Answer 44

Topical lido in a patch

Question 45

Indicated for the management of neuropathic pain associated with postherpetic neuralgia.

Answer 45

Capsaicin (Topical)

Question 46

Causes pain relief by reducing TRPV1-expressing nociceptive nerve endings, depleting the NT Substance P involved in sending pain signals to the brain. The nerve endings are damaged and can't recover for three months.

Answer 46

Capsaicin

Question 47

A receptor that is expressed on nociceptive nerve fibers in the skin/ A nociceptive pain receptor in the skin.

Answer 47

TRP-V1