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Pharm Exam 4 > Pain Characterization > Flashcards

Pain Characterization Flashcards

1
Q

Carbamezepine

A

Trigeminal neuralgia and anti-convulsant.

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2
Q

Gabapentin

A

Postherpetic neuralgia and anti-convulsant.

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3
Q

Pregabalin

A

Post-herpetic neuralgia
Diabetic neuropathy
Fibromyalgia
Spinal cord injury

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4
Q

Amitriptyline

A

Anti-depressant

Am I trippin’? No, you’re just depressed.

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5
Q

Duloxetine

A

Diabetic neuropathy
Fibromyalgia
SNRI

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6
Q

Lidocaine and Capsaicin

A

Post-herpetic neuralgia

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7
Q

This type of pain is caused by injury to body tissues.

A

Nociceptive pain

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8
Q

Most pain is _______.

A

Nociceptive

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9
Q

This pain is caused by damage to the nervous system.

A

Neuropathic

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10
Q

Pain receptors for tissue injury.

A

Nociceptors

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11
Q

Chronic pain is ___________ in nature.

A

Neuropathic

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12
Q

Most pain due to cancer us ____________.

A

Nociceptive

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13
Q

“To do harm” in Italian

A

Nuocere

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14
Q

Most chronic pain is neuropathic, except for these two things, which are nociceptive, but chronic in nature.

A

Osteoarthritis and Rheumatoid Arthritis

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15
Q

3 Types of nociceptors

A

Thermal
Mechanical
Chemical

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16
Q

Characteristic of dendrites on nociceptors.

A

NOT encapsulated

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17
Q

These drugs are used to treat nociceptive pain.

A

Acetaminophen (Tylenol)
NSAIDs
Opioids

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18
Q

This pain results from damage to the peripheral or central nervous system rather than stimulation of pain receptors.

A

Neuropathic pain

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19
Q

A painful response to a stimulus that’s not painful.

A

Allodynia

20
Q

An exaggerated painful response to a painful stimulus.

A

Hyperalgesia

21
Q

This pain results from damage to or dysfunction of the peripheral or central nervous system, rather than stimulation of pain receptors.

A

Neuropathic pain

22
Q

Common causes of neuropathic pain: (these are all in blue).

A 
Diabetic neuropathy
Postherpetic neuralgia
Facial nerve problems
MS
Chemotherapy
Amputation
HIV
Spine surgery
Alcoholism
23
Q

Two most common forms of neuropathic pain.

A

1) Postherpetic neuralgia (shingles).

2) Diabetic peripheral neuropathy

24
Q

Possible cause of trigeminal neuralgia.

A

Blood vessels compress CN V.

25
Q

These do not help treat trigeminal neuralgia.

A

Analgesics and opioids.

26
Q

First-line drug for Trigeminal Neuralgia

A

Anti-epileptic drugs

Like Carbamazepine

27
Q

This drug is anti-epileptic and is used for partial pain relief for 80-90% of people with Trigeminal Neuralgia.

A

Carbamezepine

28
Q

These 3 drugs are used to treat Chronic Neuropathic pain:

A

1) Anticonvulsant drugs
2) Anti-depressants
3) Topical lidocaine or Topical Capsaicin

29
Q

Anticonvulsant drugs

A

Carbamezepine
Gabapentin
Pentagabalin

30
Q

Antidepressants

A

Amitriptyline

Duloxetine

31
Q

Topical lido and capsaicin are used for ________.

A

Neuropathy

32
Q

Carbamezepine MOA

A

Inhibits Sodium channels on neurons, this reducing their excitability.

33
Q

The main inhibitory neurotransmitter in the CNS.

A

GABA

34
Q

What is Gabapentin used for?

A

Post-herpetic neuralgia and anti-convulsant.

35
Q

MOA of gabapentin and pregabalin.

A

Inhibit Calcium receptors, preventing the exocytosis of neurotransmitters.

36
Q

Used for the treatment of pain associated with diabetic neuropathy, postherpetic neuralgia, fibromyalgia, and neuropathic pain associated with spinal cord injury.

A

Pregabalin

37
Q

Used off-label in the treatment of trigeminal neuralgia.

A

Pregabalin

38
Q

Recommended by the Neuropathic Pain Group of the International Association for the Study of Pain (IASP) as first-line treatment for neuropathic pain.

A

Amitriptyline.

39
Q

How does Amitriptyline work?

A

Inhibits the reuptake of Serotonin and NE from the presynaptic nerve.

Also blocks cholinergic, adrenergic, and histaminergic receptors and sodium channels.

40
Q

Anticholinergic side effects (like dry mouth and eyes, urinary retention, excess sedation, orthostatic hypotension, constipation, and blurry vision) occur with these drugs.

A

Tricyclic antidepressants - Amitriptyline.

41
Q

SNRI stands for:

A

Serotonin Norepinephrine reuptake inhibitor

42
Q

A SNRI antidepressant used for diabetic neuropathy and fibromyalgia

(neuropathic pains).

A

Duloxetine

43
Q

Topical Lido MOA

A

Blocks voltage-gated Na channels.

44
Q

First line option to treat localized peripheral neuropathic pain.

A

Topical lido in a patch

45
Q

Indicated for the management of neuropathic pain associated with postherpetic neuralgia.

A

Capsaicin (Topical)

46
Q

Causes pain relief by reducing TRPV1-expressing nociceptive nerve endings, depleting the NT Substance P involved in sending pain signals to the brain.
The nerve endings are damaged and can’t recover for three months.

A

Capsaicin

47
Q

A receptor that is expressed on nociceptive nerve fibers in the skin/

A nociceptive pain receptor in the skin.

A

TRP-V1

Pharm Exam 4 (9 decks)

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