Opioid Analgesics and Drug Abuse Flashcards
I-STOP/PMP
Internet System for Tracking Over-Prescribing/Prescription Monitoring Program
T/F: Ibuprofen-APAP (which are NSAIDs) combined may be more effective analgesic than many currently available opioid-containing formulations.
True
Ibuprofen-APAP combined provided greater pain relief than did Ibuprofen or APAP alone after third molar extractions.
True
The third most commonly prescribed drug in 2015.
Hydrocodone/APAP (97m)
What is a schedule II drug?
One that may lead to abuse and dependence.
Any drug containing Hydrocodone is what schedule?
II
Prescriptions for which Schedule drugs CANNOT be refilled?
II
An addictive narcotic drug consisting of the dried juice of the opium poppy.
Opium
Any natural preparation or derivative of opium
Opiate
Opioid
Any narcotic analgesic
Raw dried opium contains _____% morphine and ___% codeine.
12 ; 1
The poppy seed has _________ and _________.
Morphine; Codeine
This opioid receptor is the principal mediator of opioid-induced:
Analgesia Resp depression Miosis Reduced GI motility Physical dependence
Mu Receptor
This substance is released as part of the pleasure center or the reward process.
Dopamine
This NT is inhibited when opioids bind to the mu receptor.
GABA
What happens when opioids binding to the mu receptor inhibit GABA?
More Dopamine is released.
Tendency of the body to adapt to the presence of opioids, making it necessary to use ever-increasing doses to achieve the same effects.
Tolerance
Tolerance develops to these things, but not to these things.
Analgesia, euphoria, respiratory depression;
Constipation and miosis
The psychological attachment to the euphoric effects of opioids.
Addiction
The body has an unpleasant withdrawal syndrome if opioids are abruptly discontinued.
Dependence
2-4h: sense of intense fear
8-16h: Increased SNS activity: nervousness, sweating, increased anxiety and fear, mydriasis
36h: skeletal muscle fasciculation, cramps, gooseflesh, increased respiration, blood sugar, metabolic rate.
48-72h: peaks and subsides over 10 days.
Opioid Withdrawal Syndrome