Medical Marijuana For Pain Flashcards
The main psychoactive component of marijuana and is highly lipophilic.
Delta 9 -THC
What components is medical marijuana characterized by?
1) THC content
2) Cannabidiol content
Non-psychoactive part of marijuana that has be used to treat seizures.
Cannabidiol
Dravat’s Syndrome
Rare form of childhood epilepsy in which cannabidiol can be used to treat.
This is now a qualifying condition for medical marijuana use.
Chronic pain
How do cannabinoids (marijuana) interact with opioids?
Prolong the effect of opioids.
What percent of marijuana users become addicted to it?
9%.
The biggest side effect in trying to stop marijuana.
Difficulty sleeping.
The types of cannabinoid receptors in the body and their location.
CB1 = CNS
CB2= PNS
The most abundant GPCR in the brain.
CB1
Endocannabinoids
2-AG
Anandamide
Cannabinoid ligands are lipopihilic or lipophobic?
Lipophilic
Where is unmetabolized THC stored?
Fat cells
Can remain in the body up to 3 months.
Type of neurotransmission in cannabinoids.
RETROGRADE
NT’s released in cannabinoid neurotransmission.
GABA, Glutamate, Dopamine
Steps in cannabinoid neurotransmission.
1) NT released (Dopamine, GABA, Glutamate) from pre-synaptic neuron.
2) Endocannabinoids (2-AG and Anandimide) released from the post-synaptic neuron.
3) Inhibit further NT release from the pre-synaptic neuron.
Breaks down 2-AG
MAGL
Breaks down Anandimide
FAAH
Opioids and cannabinoids _______.
synergize.
Benefit of taking opioids and cannabinoids together.
Cannabinoids are effective in pain relief.
Can be used in conjunction with opioids to relieve pain, thus needing less opioid dose (less dependence).
T/F: Prescribed opiates may have a much larger than anticipated effect when taken with cannabinoids.
True
What kind of pain can cannabinoids (medical marijuana) treat?
Acute, neuropathic, and inflammatory.
Effects of marijuana.
Disrupts learning and memory.
Decreased connectivity between brain regions in learning and memory.
Decreased IQ.
Respiratory issues
Effects of Marijuana on oral health.
Xerostomia Decay Leukoedema Gingivitis Alveolar bone loss Increased prevalence of candida.
T/F: Frequency recreational cannabis use is associated with deeper perio pockets, more clinical attachment loss, and higher odds of having severe periodontitis.
True
You can get _________ from consistently smoking marijuana.
Hyperemesis
Most terrible thing about synthetic marijuana.
Strong dependence
