pain

Question 1

NSAIDs indications

Answer 1

• mild to moderate pain

- inflammaotry pain

Question 2

NSAIDs MOA

Answer 2

• Inhibit COX. COX 1 = constituent. COX 2 = inducible due to inflammation. main afffects via COX2 path. som selective drugs habbe neen made e.g. etoricoxib

Question 3

SE NSAIDs

Answer 3

• GI toxicity
• renal impairment
• increased CVD event risk

non selective = ibuprofen ; lowest SE out of non selective.

naproxen and ibuprofen - lowest CVD

cox 2 SPECIFIC = Less Gi SE but more CVD.

ALL types = renal problems. hypersensitivity. fluid retenion - worsen HTN and HF

Question 4

CI NSAIDS

Answer 4

• severe renal impairment
• HF
• Liver failure
• NSAID hypersensitivity

relative - use lowest safest dose

• Peptic ulcer
• GI bleed
• CVD
• Renal impaired

Question 5

NSAID interaction

Answer 5

• with low dose; aspirin, steroids = peptic ulcer

- anticoagulants, SSRI, Venlaflaxine and renal impairment, ACE-i, diuretics = GI bleed

Question 6

general naproxen prescription in RA

Answer 6

500mg 12hrly takes 3 weeks for effects to start

Question 7

naproxen dose in acute pain

Answer 7

250mg orallly 6-8hrly