allergy

Question 1

name some h1receptor antagonists - antihistamines

Answer 1

cetirizine
loratadine
fexofenadine
chlorphenamine

Question 2

Indications of h1r antagonists - antihistamines

Answer 2

1. allergy esp hayfever
2. help pruritus and urticaria due to insect bites, infections, drug allergies
3. help in anaphylaxis after adrenaline

some are also used for Na and V

Question 3

MOA - h1receptor antagonists - antihistamines

Answer 3

antagonise h1r, block excess histamine

Question 4

SE h1r antagonists - antihistamines

Answer 4

chlorphenamine and other first gens = sedation. do not give sedating in liver disease –> hepatic encephalopathy