migraine Flashcards
1
Q
5 HTR agonists name
A
sumatriptan
2
Q
indications for serotonin 5htr agonists
A
- acute migraine with or without aura
3
Q
MOA 5htr agonists
A
- triptans contstrict cranial blood vessels and inhibit NT in peripheral trigeminal nerve in trigeminocervical complex
4
Q
SE 5HTR agonists
A
- Pain in chest and throat - can be intense but quickly resolves
- rare = MI
- N and V, tiredness, dizziness and transient high BP
5
Q
CI 5htr agonists
A
- Coronary artery disease
- cerebrovascular disease
- hemiplegic or basilar migraines
all of the above are absolute CI
6
Q
interactions of triptans
A
- with other seroteonergic drugs = increased risk of serotonin toxicity and serotonin syndrome
7
Q
dose of sumatriptan for migraines
A
- 50-100mg PO
- if vomit; SC/ intranasal
