Pain

Question 1

Nociceptive stimuli are transduced by channels in ____

Answer 1

free nerve endings

Question 2

_____ is a channel that responds to heat and capsaicin

Answer 2

TRPV1

Question 3

_____ stimuli are transmitted through small diameter, thinly myelinated or unmyelinated fibers

Answer 3

Nociceptive

Question 4

Those A-delta and C-fibers project to specific layers of the _____, where they synapse

Answer 4

spinal dorsal horn

Question 5

_____ then cross over and travel up the anterolateral tract of the spinal cord to the brainstem and thalamus.

Answer 5

Second order neurons

Question 6

the sensory pathway from finger to brain. It travels unilaterally in the spinal cord dorsal column, synapses in the _____, and the second order neuron projects from there to the ____.

Answer 6

cuneate nucleus; thalamus

Question 7

Spinothalamic (STT) and Spinoreticular nociceptive pathways travel ______ in the spinal cord

Answer 7

contralaterally

Question 8

Lateral nuclei, VPL and VPM, project to _____

Answer 8

primary and secondary somatosensory cortices

Question 9

Medial nuclei project to the _____

Answer 9

anterior cingulate cortex (ACC)

Question 10

VMpo projects to the _____

Answer 10

posterior insula

Question 11

There are also pathways that bypass the thalamus. Second order fibers in these pathways synapse in the _____ and third order neurons project to areas such as the _____.

Answer 11

brainstem (parabrachial nuclei are in the pons); hypothalamus and amygdala

Question 12

The visceral pathway is different – its second order neurons travel primarily through the _____

Answer 12

dorsal columns

Question 13

It is important to remember that the pain experience is always a combination of ___ and ____ activity

Answer 13

descending and ascending

Question 14

Pain is a multidimensional experience, with _____, _____, and _____ components

Answer 14

cognitive, affective, and sensory

Question 15

True or False? Pain consistently activates brain networks

Answer 15

True

Question 16

an exaggerated negative “mental set” brought to bear during actual or anticipated pain experience

Answer 16

pain catastrophizing

Question 17

Pain catastrophizing is associated with increased _____ activity

Answer 17

affect-related

Question 18

There does not seem to be a single brain region that codes pain like a primary sensory cortex (or “P1” cortex)
Probably the closest thing for a single region is the _____

Answer 18

posterior insula cortex (pINS)

Question 19

______ reflects vulnerability to prolonged pain

Answer 19

Peak alpha frequency