Pain Flashcards
What are 3 components of pain?
1-Sensory-descriminative2-Cognitive3-Emotional/affective
The physiological process by which information on actual/potential tissue damage is conveyed to the CNS is called?
Nociception
Specialized Ion channels on sensory nerve endings that respond to noxious stimuli are called?
Nociceptors
Pain resulting from activation of nociceptors as a result of actual or potential tissue damage and processing by the CNS is called?
Nociceptive Pain-Somatic/visceral/inflammatory
A pathophysiological process, resulting from abnormal sensory processing which does not signal actual or potential tissue damage, does not promote healing or repair and may be considered a disease is called?
Neuropathic/neurogenic pain
Pain associated with musculoskeleton system that is well defined is called?
Somatic
Pain associated with internal organs and associated tissues and is dull burning or poorly defined is called?
Visceral
The selective reduction of pain perception without affecting other sensory modalities is called?
Analgesia
The absence of any sensation due to suppression of CNS is called?
Anesthesia*Local and General
What are the 4 main steps of the nociceptive process?
TransductionTransmissionModulationPerception
What are the 4 types of ion channels that are on nerve endings?
1-Mechanical2-Chemical3-Thermal4-Polymodal
What compound found in spicy foods depletes substance P by activating the TRPV1 polymodal nociceptor?
Capsaicin*numbness following pain
Second messengers such as bradykinins are released from chemically activated nociceptor nerve endings and have what effect?
Further activate nociceptors by sensitizing them in a positive feedback
Increased perception of pain in response to a painful stimuli is called?
Hyperalgesia
Pain evoked by normally non painful stimuli is called?
Allodynia
What are two major candidates for sensitization of nerve endings?
1-Substance p (SP) (nerve endings)2-Prostaglandins (damaged cells)
What affect to PGs have on nerve endings?
Activate Na channels making the cell more excitable
Which protein is a constitutive in many tissues, generates PGs for regulation, is inhibited by classic NSAIDs and is the basis of some adverse effects of NSAIDs?
COX-1*Aspirin blocks both COx1 and 2 but is more effective on 1