Pain

Question 1

nociception

pain

Answer 1

• detection, transduction, and transmission noxious stimulus

- perception of nociception occuring in brain

Question 2

acute pain
chronic pain
neuropathic pain

Answer 2

1. 6 weeks. nociceptive or neurpathic
2. PNS or CNS burning, lanciating, shooting, tingeling.
   - allodynia: pain with normal stimuli
   - hyperalgesi - increased sensitivity to painful stimuli

Question 3

Opiods

• ex
• indic
• mech
• side effect, tox

Answer 3

• codeine, oxycodein, morphine, fentanyl, remifentanyl
• moderate acute pain, moderate-severe acute pain
• dampens nociceptive transmission between 1st and 2nd neuron in dorsal horn. activate ascending modulatory pathway rekease of inhib neurotransmitters. inhibit periph inflamm response and hyperalgesia. affect mood and anxiety-
• resp depression, const abd pain, sedation, N/V, pruritus, confusion, dependence

Question 4

Acetaminophen

• ex
• indic
• mech
• side effect, tox

Answer 4

• tylenol, paracept. selective cox-2 inhibition

- safe, liver toxicity

Question 5

NSAIDS

• ex
• indic
• mech
• side effect, tox

Answer 5

• aspirin, etc.cox 1 og cox 2 inhibition, produce proinfamm prostaglandin synth
• tox: gastric ulcer, decreased renal perfusion, photosensitivity, premature closure DA