complications

Question 1

Malignant hyperthermia

1. def
2. cause
3. clinics
4. complications
5. prevention
6. management

Answer 1

1. hypermetabolic disorder of skeletal muscle. uncontrolled increase in ca2+ intracelluar
2. AD heritance, assoc with skeletal muscle abn. usually succ and inhalation drugs except NO
3. increased o2 consumption, hypertermia, increased etco2, tachypne, tachycardia, increased BP, cyanosis, muscular symp-trimus, swollen -rhabdo, hyperkalemia
4. coma, DIC, rhabdo, renal failure, ARDS, pulm edema
5. Family history test, avoiding triggers
6. hyperventilate, dantrolene, bicarb, cooling, stop agent obviously

Question 2

abn pseudocholinesterase

1. function

Answer 2

hydrolyze SCh and mivacurium
heterozygot - prolonged muscular blockade
homozygot - greatly increased duration
NB! no antidot… continue ventilate and maintain under anesth