Pain Flashcards
Pain definition
Subjective sensation of nociceptive stimulus
TRP acronym
Transient Receptor Protein
TRP types
TRP v1
TRP M (‘M’ = menthol)
TRP v1
Chilli pain receptors
TRP M
Cold
Pain nerve fibre classification
C fibres
A delta
C nerve fibre qualities
Non-myelinated
Slower longer onset of pain
A delta nerve fibre qualities
Myelinated -
Quicker shorter onset of pain
Common pain nerve fibres in viscera
C
Common pain nerve fibres in skin
A delta
Pathway of pain signal - Pain cascade
Nerve ending impulse ->
Dorsal root ganglion (glutamate in synapse) ->
Decussates at level of spinal cord ->
Spinothalamic tract ->
Thalamus ->
Signal splits to multiple parts of the brain:
- Cortex
- Periaqueductal grey
- Nucleus Raphe Magnus
- Locus Coeruleus
Excitatory synaptic neurotransmitter
Glutamate
Inhibitory synaptic neurotransmitter
GABA
Gate control theory of pain site
Substantia gelatinosa
Nerve input to substantia gelatinosa
A delta pain fibre
A beta motor fibre
Periaqueductal grey via Nucleus Raphe Magnus
Locus coeruleus