Pain Flashcards

1
Q

Pain definition

A

Subjective sensation of nociceptive stimulus

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2
Q

TRP acronym

A

Transient Receptor Protein

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3
Q

TRP types

A

TRP v1
TRP M (‘M’ = menthol)

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4
Q

TRP v1

A

Chilli pain receptors

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5
Q

TRP M

A

Cold

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6
Q

Pain nerve fibre classification

A

C fibres
A delta

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7
Q

C nerve fibre qualities

A

Non-myelinated
Slower longer onset of pain

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8
Q

A delta nerve fibre qualities

A

Myelinated -
Quicker shorter onset of pain

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9
Q

Common pain nerve fibres in viscera

A

C

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10
Q

Common pain nerve fibres in skin

A

A delta

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11
Q

Pathway of pain signal - Pain cascade

A

Nerve ending impulse ->

Dorsal root ganglion (glutamate in synapse) ->

Decussates at level of spinal cord ->

Spinothalamic tract ->

Thalamus ->

Signal splits to multiple parts of the brain:
- Cortex
- Periaqueductal grey
- Nucleus Raphe Magnus
- Locus Coeruleus

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12
Q

Excitatory synaptic neurotransmitter

A

Glutamate

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13
Q

Inhibitory synaptic neurotransmitter

A

GABA

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14
Q

Gate control theory of pain site

A

Substantia gelatinosa

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15
Q

Nerve input to substantia gelatinosa

A

A delta pain fibre
A beta motor fibre
Periaqueductal grey via Nucleus Raphe Magnus
Locus coeruleus

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16
Q

Location of periaqueductal grey

A

Around 3rd ventricle to base of brain stem

17
Q

Neurotransmitter for Nucleus Raphe Magnus

A

Serotonin

18
Q

Neurotransmitter for Locus Coeruleus

A

Noradrenaline

19
Q

Receptor present in substantia gelatinosa

A

NMDA

20
Q

NMDA receptor qualities

A

Ionotropic receptor (not g protein coupled)
Glutamatergic
Particularly permeable to Calcium ions (and Sodium)

21
Q

How does Magnesium inhibit NMDA receptor

A

Magnesium and 2+ charge (same as Calcium) but is larger in size so does not pass Magnesium

Electrochemical gradient attracts Magnesium but blocks receptor

Competes with calcium but does not permeate

Use dependant blockade of NMDA receptors

22
Q

Action of intravenous Lidocaine at non cardiotoxic doses

A

NMDA receptor antagonist

23
Q

Ketamine mode of action

A

NMDA receptor antagonist

24
Q

Methods to reduce pain in peripheral nerve tissue

A

Regional block
Reduce size of incisions
Anti-inflammatories (NSAIDs, Dexamethasone)

25
Q

Drugs

A
26
Q

Types of opioid receptors

A

Mu opioid receptor
Kappa opioid receptor
Delta opioid receptor

27
Q

Opioid receptor qualities and action

A

Pre-synaptic G coupled metabotropic receptor
Gi (inhibitory)
Reduces cyclic AMP action
Reduces voltage gated calcium channel action

28
Q

Location of action of opioid receptors

A

Spinal level - receptors in substantia gelatinosa

Further in pain cascade - inhibitory action on locus coeruleus

29
Q

Mode of action of clonidine

A

Alpha 2 receptor agonist

30
Q

Effects of clonidine

A

Anxiolytic - reduced sympathetic drive

Analgesia - not 100% know but possible reduced noradrenaline action (eg from locus coeruleus

31
Q

Analgesia option which effects Nucleus Raphe Magnus and Locus coeruleus

A

Tricyclic antidepressants - Amitriptyline
Duloxetine

Mixed SNRI effects

32
Q

Plane block definition

A

Anaesthetise ‘plane’ / area rather than specific nerve

More conducive to catheter insertion as less risk than when placed directly to nerve

33
Q

Approach to regional block pain calls

A

Check block area with ethyl chloride spray
Does level of block need to increase (more volume, lower concentration)
Does level of analgesia need to increase (less volume, higher concentration)