AWABS - Analgesics

Question 1

Arachidonic acid pathway of NSAID mechanism of action

Answer 1

Question 2

Classification of NSAIDs

Answer 2

Non-selective NSAIDS
COX-2 selective NSAIDs

Question 3

Examples of non-selective NSAIDs

Answer 3

Diclofenac
Diflunisal
Etodolac
Fenoprofen
Ibuprofen
Indomethacin
Ketoprofen

Question 4

Examples of COX-2 selective NSAIDs

Answer 4

Celecoxib
Rofecoxib

Question 5

Classification of opioids according to function

Answer 5

Question 6

Graph representing context sensitive half life of opioid infusions

Answer 6

Question 7

Codeine features

Answer 7

Methylmorphine
Pro-drug
Multiple metabolism pathways
Exhibits genetic polymorphism
Contraindicated in paeds

Question 8

One metabolism pathway of codeine

Answer 8

5-15% metabolised to active drug and reliant cytochrome p450

Question 9

Genetic polymorphism definition in relation to codeine

Answer 9

Different genetics affect metabolism of codeine

Question 10

Tramadol features

Answer 10

Mu receptor agonist
Also SNRI
Can precipitate serotonin syndrome

Question 11

Features of partial opioid agonist

Answer 11

Affinity for opioid receptor but not full affinity of full agonists
Have ceiling effect

Question 12

Opioid equivalence conversions

Answer 12

Question 13

Pain fibre termination site in cord laminae

Answer 13

A delta fibres terminate in rexed lamina I and V (1 and 5)

C fibres terminate in rexed lamina I and II

Question 14

Allodynia definition

Answer 14

Painful response to a normally non-painful stimulus

Question 15

Hyperalgesia definition

Answer 15

Disproportionately high painful response following a painful stimulus

Question 16

Nociceptors definition

Answer 16

Free nerve endings of primary afferents

Question 17

Opioid receptors

Answer 17

G protein coupled to ion channels

Question 18

Intrathecal and Epidural equivalent opioid dose compared to IV opioid

Answer 18

Intrathecal 100x more effective
Epidural 10x more effective