Page 6 - Steroidgenesis & Regulation of Glucocorticoids

Question 1

The binding of ACTH triggers

Answer 1

Steridogenesis

Question 2

During steridogenesis _ _ is converted to __s using ___ and ___-__

Answer 2

Free cholesterol, GCs, CYPs, 3B-HSD

Question 3

The glucocorticoid produced in mammals and fish is?

Answer 3

Cortisol

Question 4

The glucocorticoid produced in birds is?

Answer 4

Corticosterone

Question 5

GCs alter a range of physiological responses such as ,,-, and _ to help deal with the stressor and restore homeostasis

Answer 5

metabolism, behaviour, anti-inflammatory and immunosuppressive

Question 6

GCs are controlled by _ _ _ _ (MR) and _ _ _ _ (GR)

Answer 6

high affinity mineralocorticoid receptors, low affinity glucocorticoid receptors

Question 7

MRs and GRs can act as _ _ _ for unique sets of genes

Answer 7

nuclear transcription factors

Question 8

Expression of MR and GR and their ratio influences the _ of GCs within different tissues.

Answer 8

Bioactivity

Question 9

GCs like Catecholamines are _ regulated

Answer 9

tightly

Question 10

Methods of GCs Regulation

Answer 10

MRs & GRs, hepatic binding protein

Question 11

Hepatic binding proteins used

Answer 11

Cortisol Binding Protein (CBG) and Albumin

Question 12

In a non-stressed state albumin and CBG sequester __% of GCs

Answer 12

95

Question 13

In times of stress ___ is released to buffer effects of GCs

Answer 13

CBG

Question 14

Once CBG become _ the effects of GCs and [GCs] _

Answer 14

saturated, increases