PACES: Obstetric Monitoring Flashcards
What screening occurs at booking, for those women who choose to have it?
Blood tests: group, RhD status, FBC (anaemia), Hb electrophoresis (SCA/Thal), infection (hep B, HIV, syphilis)
Urine dip + MC&S: proteinuria? Asymptomatic bacteriuria?
What supplementation should women be on? (checked at the booking visit)
Folic acid 400 μg OD
Vitamin D 10 μg OP
In which patients should folic acid supplementation be increased? What is the dose?
5mg OD
Previous NTD
Sickle cell disease
BMI >30
Diabetic
Either parent has NTD
On Anti-epileptics
When is the dating scan, and what can it screen for?
11+2 - 14+1w
Viability
Gestation
Multiple pregnancy (+ chorionicity)
Nuchal translucency
What are the 3 elements of the ‘triple test’?
USS (for nuchal translucency)
Blood test for B-hCG + PAPP-A
What combined test result suggests Downs syndrome?
High NT
High B-hCG
Low PAPP-A
What combined test result suggests Edwards or Patau syndrome?
High NT
Low B-hGC
Low PAPP-A
During which weeks of gestation can the combined test be carried out?
11+0 - 13+6
When is NIPT offered on the NHS?
If combined or quadruple test indicate high risk >1/150
What does NIPT analyse?
Small DNA fragments circulating in blood of pregnant woman (cell free fetal DNA, cffDNA)
cffDNA derives from placental cells + is usually identical to fetal DNA
Sensitivity + specificity are very high for trisomy 21 (>99%) + similarly high for other chromosomal abnormalities
What diagnostic tests can confirm Down syndrome? When is each used?
Chorionic Villous Sampling: 10-15w
Amniocentesis: 15-20w
What can be offered if a woman books late and misses the opportunity for a combined test?
Quadruple test (used to be Triple)
What are the components measured in the quadruple test?
Alpha-fetoprotein (AFP)
Total human chorionic gonadotophin (hCG)
Unconjugated oestriol (uE3)
Inhibin-A (inhibin)
What results of the quadruple test indicate Down syndrome?
AFP: LOW
hCG: HIGH
Inhibin: HIGH
Oestradiol: LOW
What results of the quadruple test indicate Edward’s syndrome?
AFP: LOW
hCG: LOW
Inhibin: Normal
Oestradiol: LOW
What results of the quadruple test indicate Neural Tube defects?
AFP: HIGH
hCG: Normal
Inhibin: Normal
Oestradiol: Normal
At how many weeks is the anomaly scan?
18-20w
What is looked for on the anomaly scan?
Structural anomalies
Placental location
Amniotic liquor volume
Gender + growth of foetus