Oxygenation Flashcards
Hypoxemia
decrease of oxygen concentration in the blood
Ventilation
the movement of air into and out of the lungs for the purpose of delivering fresh air into the lungs alveoli
Inhalation
initiated when the diaphragm contracts, increasing the size of the intrathoracic space; decreases intrathoracic pressure so air can be drawn in from the atmosphere
Exhalation
respiratory muscles relax, increasing intrathoracic pressure and forcing air to exit
Work of breathing
increased when additional muscle forces are required for breathing; otherwise passive process
Oxygen uptake
exchange of oxygen from the alveolar space into the pulmonary capillaries; also known as external respiration; carbon dioxide travels the opposite way during this sequence
Oxygen in plasma
expressed as partial pressure of oxygen; normal in arterial blood is 80-100mm Hg
Hemoglobin
the vast majority of oxygen is carried through the blood bound to hemoglobin; it’s expressed as a %- normal saturation is between 96-98%
Oxyhemoglobin dissociation curve
the relationship between dissolved O2 in plasma (PaO2) and O2 saturation
Oxygen release in the blood
as O2 rich blood circulates in the peripheral capillaries, dissolved O2 diffuses out of the blood; this causes hemoglobin to lose the affinity to be bound to O2 and the O2 is released to the body’s cells
Circulation
the function of the heart and blood vessels
Cardiac cycle
cycle of atrial and ventricular contraction and relaxation
Diastole
the process of a chamber filling
Systole
the process of the chamber emptying
Physiology of oxygenation
alveoli-capillary bed of lungs-pulmonary veins-left atrium-left ventricle-aorta- arteries- arterioles- capillary bed of tissues- cells of the body tissue
Precapillary sphincters
rings of smooth muscle around the arterioles; blood flow to specific organs may be increased or redused by the relaxation or constriction of these sphincters
Internal respiration
O2 diffuses from the blood to the tissues; CO2 moves from the tissues to the blood
Obstructive pulmonary disease
the airways become partially or completely blocked, diminishing airflow, or the lungs lose some of their elastic recoil which traps stale air that should be exhaled; common types are asthma, emphysema, chronic bronchitis- collectively known as COPD
Restrictive pulmonary disease
pathologies that impair theability of the chest wall and lungs to expand during the inspiratory phase of ventilation; increases the work of breathing; reduces airflow to alveoli
Ventilation-perfusion mismatching
balance between amount of fresh air entering the alveoli and the amount of blood flow to various regions of the pulmonary capillary network; this is not uniform throughout the lungs so some areas of the lungs may have better ventilation than others at any given time
Atherosclerosis
narrowing and eventual occlusion of hte lumen by deposits of lipids, fibrin and calcium on the interior walls of the arteries; most common cause of altered arterial circulation