Oxidative Phosphorylation Flashcards
The _____ consists of a series of 4 large multi-protein complexes located in the inner mitochondrial membrane.
electron transport chain
The electron transport chain consists of a series of 4 large multi-protein complexes located in the _____.
inner mitochondrial membrane
What are the substrates for oxidative phos?
NADH FADH2 O2 Pi ADP
What are the products for oxidative phos?
NAD
FAD
H2O
ATP
ATP synthesis is inhibited by the drug ______ which causes NADH and FADH2 to accumulate and reduce flux thru TCA.
oligomycin
_____ results in an inability of hemoglobin to release O2. This inhibits the electron transport chain while blood pO2 remains high.
Carbon monoxide poisoning
_____ allow the proton gradient across the inner mitochondrial membrane to dissipate without coupling to ATP generation resulting in loss of the chemical energy as heat.
Uncoupling proteins
What is the mechanism used by brown adipose tissue to generate heat?
uncoupling
What is respiratory control?
tight coupling of electron flow and ATP synthesis in mitochondria assures that O2 consumption depends on the availability of ADP
Low ADP/high ATP _____ flow of electrons, which ____ O2 consumption.
decreases, decreases
_______ decreases flow of electrons, which decreases O2 consumption.
Low ADP/high ATP
How does overnutrition affect the mitochondria?
generation of oxygen free radicals –> cell injury, aging, apoptosis
How does exercise affect the mitochondria?
increased oxidative capacity, less free radical build up,, increased muscle mitochondria content
What is one of the key mediators of mitochondrial proliferation?
PGC1alpha
Hypocaloric diets might limit the generation of _____ which potentially injure cells and tissues.
free radicals
