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BIOCHEM TEST 3 > oxidative metabolism-TCA > Flashcards

oxidative metabolism-TCA Flashcards

1
Q

main intermediate for TCA

A

Acetyl Coa

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2
Q

products of TCA

A

2 CO2
3 NADH
FADH2
GTP

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3
Q

Which pathway stops without oxygen

A

aerobic

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4
Q

3 major process of oxidative metabolism

A
  1. acetyl coa is made
  2. acetyl coa is oxidized and gives off energy
  3. enery is used to make ATP
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5
Q

Prosthetic groups of succinate dehydrogenase

A

FMN
FAD
FADH2

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6
Q

Which enzyme is NOT in the mitochondrial matrix?

A

succinate dehydrogenase

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7
Q

vitamins used in TCA

A

VIT B3
VIT B2
PANTOTHENIC ACID
VIT B1

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8
Q

Allosteric enzymes of TCA

A

isocitrate dehydrogenase, a-ketoglutarate dehydrogenase

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9
Q

precursors for citrate synthase

A

acetyl coa, oxaloacetate

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10
Q

products of citrate synthase

A

citrate

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11
Q

enzymes in citrate synthase

A

citrate synthase

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12
Q

activators of citrate synthase

A

oxaloacetate, ADP

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13
Q

Inhibitors of citrate synthase

A

NADH
ATP
CITRATE
SUCCINYL-COA

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14
Q

Precursor for fluoroacetate

A

citrate

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15
Q

product for fluoroacetate

A

isocitrate

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16
Q

enzyme for fluoracetate

A

aconitase

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17
Q

inhibitor of fluoracetate

A

fluoroacetate (when converted to fluoroacetate, inactivates aconitase)

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18
Q

precursors of isocitrate dehydrogenase

A

isocitrate

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19
Q

products of isocitrate dehydrogenase

A

a-ketogluterate

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20
Q

enzymes of isocitrate dehydrogenase

A

isocitrate (2nd regulatory enzyme)

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21
Q

allosteric activators of isocitrate dehydrogenase

A

AMP, ADP

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22
Q

Inhibitors of isocitrate dehydrogenase

A

NADH, ATP

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23
Q

precursor of succinyl-coa

A

a-ketoglutarate

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24
Q

products of succinyl-coa

A

succinyl-coa, co2 (last carbon from original glucose)

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25
Q

enzyme of succinyl-coa

A

a-ketoglutarate dehydrogenase (uses 2 coenzymes and 3 prosthetic groups)

26
Q

coenzymes of a-ketoglutarate dehydrogenase

A

COA-SH, NAD+

27
Q

prosthetic groups of a-ketoglutarate dehydrogenase

A

FAD+, Lipoamide, TPP (B1)

28
Q

Activators of a-ketoglutarate dehydrogenase

A

NAD+, ADP

29
Q

Inhibitors of a-ketoglutarate dehydrogenase

A

NADH, ATP, Succinyl-CoA

30
Q

Only energy-yielding step of the cycle that makes GTP

A

substrate level phosphorylation (formation of succinate)

31
Q

precursor of substrate level phosphorylation

A

succinyl-coa

32
Q

products of substrate level phosphorylation

A

succinate, GTP, Free CoA

33
Q

enzyme of substrate level phosphorylation

A

succinyl-CoA synthetase

34
Q

Third oxidation step of the TCA

A

succinate dehydrogenase

35
Q

prosthetic groups of succinate dehydrogenase

A

FMN, FAD, FADH2

36
Q

Precursor to the hydration of fumarate (step 7)

A

fumarate

37
Q

products of step 7

A

malate

38
Q

enzymes of step 7

A

fumerase

39
Q

enzymes of step 8 (oxidation of malate)

A

malate dehydrogenase

39
Q

product of step 8 (oxidation of malate)

A

oxaloacetate

40
Q

precursor of step 8 (oxidation of malate)

A

malate

41
Q

precursors of TCA

A

acetyl-CoA
3 (NAD+)
FAD
GDP
Pi
2(H2O)

42
Q

Products of TCA

A

2 (CO2)
3 (NADH)
FADH2
GTP
2 (H+)
CoA-SH

43
Q

What reactions have negative ve values and favor forward rxn, they are also the rate limiting enzymes

A

reactions catalyzed by: citrate synthase, isocitrate dehydrogenase, a-ketoglutarate dehydrogenase

44
Q

activators of citrate synthase

A

ADP, Oxaloacetate

45
Q

inhibitors of citrate synthase

A

NADH, ATP, Citrate, succinyl-CoA

46
Q

activators of isocitrate dehydrogenase

A

NAD+, ADP, Ca2+

47
Q

inhibitors of isocitrate dehydrogenase

A

NADH, ATP

48
Q

activators of a-ketoglutarate dehydrogenase

A

NAD+, ADP, Ca2+

49
Q

inhibitors of a-ketoglutarate dehydrogenase

A

NADH, ATP, Succinyl-CoA

50
Q

control point outside of TCA

A

Pyruvate dehydrogenase

51
Q

9 activators of TCA

A

Oxaloacetate
ADP
NAD+
Ca2+
a-ketoglutarate dehydrogenase
coenzyme A
NAD+
TPP (B1)
Lipoamide
FAD

52
Q

4 inhibitors of TCA

A

ATP
NADH
Succinyl-CoA
citrate

53
Q

3 major mechanisms that regulate TCA

A

substrate availability
product inhibition
competitive feedback

54
Q

additional regulatory mechanisms in TCA

A

Demand for ATP
Availability of oxygen
activity of rate-limiting enzymes in the cycle

55
Q

what is a-ketoglutarate converted to in the brain

A

GABA

56
Q

what is a-ketoglutarate converted to then sent through the blood

A

glutamine

57
Q

product of the most exergonic rxn of TCA

A

Succinyl-CoA

58
Q

during fasting, what is gluconeogenic precursors converted to?

A

malate

59
Q

which intermediates does TCA us for carbon skeletons of AA?

A

succinyl-CoA
glycine

BIOCHEM TEST 3 (6 decks)

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