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oxidative metabolism-TCA Flashcards

1
Q

main intermediate for TCA

A

Acetyl Coa

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2
Q

products of TCA

A

2 CO2
3 NADH
FADH2
GTP

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3
Q

Which pathway stops without oxygen

A

aerobic

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4
Q

3 major process of oxidative metabolism

A
  1. acetyl coa is made
  2. acetyl coa is oxidized and gives off energy
  3. enery is used to make ATP
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5
Q

Prosthetic groups of succinate dehydrogenase

A

FMN
FAD
FADH2

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6
Q

Which enzyme is NOT in the mitochondrial matrix?

A

succinate dehydrogenase

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7
Q

vitamins used in TCA

A

VIT B3
VIT B2
PANTOTHENIC ACID
VIT B1

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8
Q

Allosteric enzymes of TCA

A

isocitrate dehydrogenase, a-ketoglutarate dehydrogenase

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9
Q

precursors for citrate synthase

A

acetyl coa, oxaloacetate

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10
Q

products of citrate synthase

A

citrate

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11
Q

enzymes in citrate synthase

A

citrate synthase

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12
Q

activators of citrate synthase

A

oxaloacetate, ADP

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13
Q

Inhibitors of citrate synthase

A

NADH
ATP
CITRATE
SUCCINYL-COA

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14
Q

Precursor for fluoroacetate

A

citrate

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15
Q

product for fluoroacetate

A

isocitrate

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16
Q

enzyme for fluoracetate

A

aconitase

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17
Q

inhibitor of fluoracetate

A

fluoroacetate (when converted to fluoroacetate, inactivates aconitase)

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18
Q

precursors of isocitrate dehydrogenase

A

isocitrate

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19
Q

products of isocitrate dehydrogenase

A

a-ketogluterate

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20
Q

enzymes of isocitrate dehydrogenase

A

isocitrate (2nd regulatory enzyme)

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21
Q

allosteric activators of isocitrate dehydrogenase

A

AMP, ADP

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22
Q

Inhibitors of isocitrate dehydrogenase

A

NADH, ATP

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23
Q

precursor of succinyl-coa

A

a-ketoglutarate

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24
Q

products of succinyl-coa

A

succinyl-coa, co2 (last carbon from original glucose)

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25
enzyme of succinyl-coa
a-ketoglutarate dehydrogenase (uses 2 coenzymes and 3 prosthetic groups)
26
coenzymes of a-ketoglutarate dehydrogenase
COA-SH, NAD+
27
prosthetic groups of a-ketoglutarate dehydrogenase
FAD+, Lipoamide, TPP (B1)
28
Activators of a-ketoglutarate dehydrogenase
NAD+, ADP
29
Inhibitors of a-ketoglutarate dehydrogenase
NADH, ATP, Succinyl-CoA
30
Only energy-yielding step of the cycle that makes GTP
substrate level phosphorylation (formation of succinate)
31
precursor of substrate level phosphorylation
succinyl-coa
32
products of substrate level phosphorylation
succinate, GTP, Free CoA
33
enzyme of substrate level phosphorylation
succinyl-CoA synthetase
34
Third oxidation step of the TCA
succinate dehydrogenase
35
prosthetic groups of succinate dehydrogenase
FMN, FAD, FADH2
36
Precursor to the hydration of fumarate (step 7)
fumarate
37
products of step 7
malate
38
enzymes of step 7
fumerase
39
enzymes of step 8 (oxidation of malate)
malate dehydrogenase
39
product of step 8 (oxidation of malate)
oxaloacetate
40
precursor of step 8 (oxidation of malate)
malate
41
precursors of TCA
acetyl-CoA 3 (NAD+) FAD GDP Pi 2(H2O)
42
Products of TCA
2 (CO2) 3 (NADH) FADH2 GTP 2 (H+) CoA-SH
43
What reactions have negative ve values and favor forward rxn, they are also the rate limiting enzymes
reactions catalyzed by: citrate synthase, isocitrate dehydrogenase, a-ketoglutarate dehydrogenase
44
activators of citrate synthase
ADP, Oxaloacetate
45
inhibitors of citrate synthase
NADH, ATP, Citrate, succinyl-CoA
46
activators of isocitrate dehydrogenase
NAD+, ADP, Ca2+
47
inhibitors of isocitrate dehydrogenase
NADH, ATP
48
activators of a-ketoglutarate dehydrogenase
NAD+, ADP, Ca2+
49
inhibitors of a-ketoglutarate dehydrogenase
NADH, ATP, Succinyl-CoA
50
control point outside of TCA
Pyruvate dehydrogenase
51
9 activators of TCA
Oxaloacetate ADP NAD+ Ca2+ a-ketoglutarate dehydrogenase coenzyme A NAD+ TPP (B1) Lipoamide FAD
52
4 inhibitors of TCA
ATP NADH Succinyl-CoA citrate
53
3 major mechanisms that regulate TCA
substrate availability product inhibition competitive feedback
54
additional regulatory mechanisms in TCA
Demand for ATP Availability of oxygen activity of rate-limiting enzymes in the cycle
55
what is a-ketoglutarate converted to in the brain
GABA
56
what is a-ketoglutarate converted to then sent through the blood
glutamine
57
product of the most exergonic rxn of TCA
Succinyl-CoA
58
during fasting, what is gluconeogenic precursors converted to?
malate
59
which intermediates does TCA us for carbon skeletons of AA?
succinyl-CoA glycine

BIOCHEM TEST 3 (6 decks)

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