AMINO ACID METABOLISM Flashcards
what is the first step of amino acid catabolism?
removal of alpha-amino groups
can be used to synthesize glucose
glycogenic
amino acids that are only ketogenic
leucine and lysine
amino acids that are both ketogenic and glucogenic
tryptophan
threonine
phenylalanine
tyrosine
isoleucine
major intermediates for carbon skeleton
pyruvate, oxaloacetate, a-ketoglutarate, succinyl coa, fumerate, acetyl coa, acetoacetyl coa
where are branched amino acids metabolized primarily
the muscle
coenzymes in aa catabolism
h4 folate
b12
s-adenosylmethionine
biotin
tetrahydrobiopterin
build up of homogentisic acid in the body causing parts of the body to turn dark
alkaptonuria, black urine disease
defect in the branched chain aa degradation pathway (affects infants)
ketoaciduria, maple syrup urine disease
buildup of phenylalanine in the tissue, plasma, and urine because of a deficiency of phenylalanine hydroxylase
phenylketonuria, PKU
defect in tyrosine metabolism results in deficiency in melanin production
albinism
which non-essential aa can be built from essential aa
tyrosine from phenylalanine
cysteine (depends on s) from methionine
what is synthesis from a-keto called?
transamination
what is synthesis from other aa called?
amination
disruption in dopamine receptors will cause what?
parkinson’s disease
