Overview Of The Immune System Flashcards
What are the two systems of Immunity?
Innate and Adaptive
What are the physical Barriers?
Skin, Mucosal linings of gastrointestinal tract, genitourinary tract and upper respiratory tract.
The white blood cells of the innate system are?
(Seen in a CBC)
Monocytes, granulocytes and Natural Killer
The granulocytes counted in a CBC cell differential are?
Neutrophils, eosinophils and basophils.
What is the ‘complement’ system?
Over thirty proteins made mostly in the liver to help immune cells.
What are cytokines?
Eg: Interlukins, interferon, tumour necrosis factor etc
They’re cell to cell chemical mediators made by immune cells to influence the actions of other cells.
What are monocytes?
WBC
When they leave blood circulation they migrate into tissues and becomes macrophages
What are granulocytes?
Most abundant WBC.
Concentrate on site of infection.
Neutrophils/Eosinophils/Basophils
What are neutrophils?
Most numerous cell line in differential.
Clear bacteria and fungi
Intense inflammation
Association with Pus
What are eosinophils?
Fights parasitic infection
Regulates histamine and helps regulate the release of histamine
What are basophils?
Release cytotoxic granules towards parasites.
Contains histamine
What are natural killer cells?
Part of innate immune system
Surveillance of cancerous cells.
Initial response to viral infections
What’s the adaptive Immune system?
Develops after birth
Antibodies and molecular mediators works with innate system.
Vaccines as example
Develop memory cells
What are the cells and products of the Adaptive Immune System?
B-Lymphocyte, Immunoglobulin/Antibody, T-Lymphocytes (including cytotoxic t-cells and helper t-cells), HLA and MHC.
What are B-Lymphocytes?
Lymphocytes that mature in the Bone marrow.
Matures further into plasma cells
Provides immunity by producing antibodies
