Overview of Organ System Metabolism

Question 1

Propose consequences of the brain being a highly aerobic organ

Answer 1

brain would be first organ to go with lack of oxygen

Question 2

Describe the anaerobic and aerobic metabolism of skeletal muscle

Answer 2

anaerobic: glucose from gluconeogenesis in liver
aerobic: acetyl CoA from ketone bodies & fatty acids vis B-oxidation; glucose from glycogenolysis and gluconeogenesis

Question 3

Describe the shuttling of lactate, alanine, glutamine and glucose between skeletal muscle and liver during fasting and exercise

Answer 3

• Cori Cycle - glucose goes to skeletal muscle for glycolysis and formation of lactate relieves the system of NADH+H+…lactate travels to liver to help with gluconeogenesis and relieves the cells of NAD
• alanine and glutamine are made in skeletal muscle in alanine cycle and sent to the liver for excretion as urea

Question 4

Describe the shuttling of ketone bodies from liver to skeletal muscle during times of fasting or exercise

Answer 4

?

Question 5

Analyze the evidence for cardiac muscle dependence on aerobic metabolism

Answer 5

1/2 the cytosol is taken up by mitochondria

Question 6

Compare and contrast the function of white versus brown adipose tissues

Answer 6

White: store TAGs, helps produce chemical energy
Brown: produces heat energy

Question 7

Describe the dependence of muscle and brain metabolism on creatine

Answer 7

pH buffer for all the lactate being produced (lowered pH)
biosynthesis and dietary uptake of creatine contribute, as well as phosphocreatine which uses creatine kinase and ADP to make creatinine and ATP

Question 8

Identify the importance of dietary molecules delivery from intestines to liver

Answer 8

liver needs things first – hepatic portal vein

Question 9

Interrelate the catabolic and anabolic roles of liver for the body

Answer 9

know what the liver does