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Lindsey's Blood and Lymph Unit III > Overview of Lymphoid Neoplasms/Hodgkin and non-Hodgkin > Flashcards

Overview of Lymphoid Neoplasms/Hodgkin and non-Hodgkin Flashcards

1
Q

____ is a T-cell marker that highlights abundant T-cells in the paracortex and scatter T-cells in the germinal center.

A

CD3

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1
Q

What is MCL?

A

B-cell neoplasm of small to medium-sized lymphocytes

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1
Q

What is MGUS?

A

monoclonal Ig in the serum or urine in pt w/o evidence of plasma cell neoplasms

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2
Q

In FL, the B cells will express _____, _____, _____, ____, and _____.

A

CD19, CD20, BCL2, CD10, BCL6

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3
Q

The ______ pattern is seen in BL.

A

starry-sky

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3
Q

What is solitary plasmacytoma of bone?

A

localized tumor of bone, composed of clonal plasma cells similar to those in plasma cell myeloma

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5
Q

What is BCL2?

A

an oncogene that induces follicular lymphoid hyperplasia

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5
Q

B-cells in MCL typically express ____, ____, and ____ but do not express ____.

A

CD19, CD20, CD5; CD23

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6
Q

What is Hodgkin’s Lymphoma?

A

4 types of germinal center B-cell neoplasms; Reed-Sternberg cells are diagnostic

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7
Q

The ____ deletion is the most common genetic alteration in CLL and has a favorable prognosis.

A

13q14

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8
Q

Translocations of the _____ on chromosome 8 at band 8q24 are a constant feature of Burkitt’s Lymphoma.

A

MYC oncogene

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9
Q

What is Burkitt’s Lymphoma?

A

highly aggressive B-cell lymphoma, presenting as extranodal sites or a leukemic form

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10
Q

MCL is characterized by the _____ gene rearrangement at _____, leading to a constant overexpression of cyclin D1.

A

BCL1; 11q13

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11
Q

CLL will have B-cells positive for ____, ____, and ____.

A

CD5, CD23, CD19

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12
Q

What does NSHL stand for?

A

nodular sclerosis CHL

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13
Q

What are the most frequent s/s of plasma cell neoplasms?

A

bone pain the back or extremities, weakness, tiredness, anemia

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13
Q

What does NLPHL stand for?

A

nodular lymphocyte-predominant Hodgkin’s Lymphoma

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14
Q

What are the 4 subtypes of Classical Hodgkin’s Lymphoma (CHLs)?

A
  1. nodular sclerosis classical Hodgkin’s Lymphoma 2. lymphocyte-rich classical Hodgkin’s Lymphoma 3. mixed cellularity classical Hodgkin’s Lymphoma 4. lymphocyte-depleted classical Hodgkin’s Lymphoma
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15
Q

What is cyclin D1?

A

it’s important in tumor development

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15
Q

Endemic BL can affect the ____ and _____ bones, and the _____, ____, and _____.

A

jaw; other facial; distal ileum, cecum, omentum

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15
Q

What is a Reed-Sternberg cell?

A

large, up to 100microm, multiple or lobated nuclei; ample cytoplasm

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17
Q

Efferent means ____.

A

away

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18
Q

What is a plasma cell myeloma?

A

bone marrow based, multifocal plasma cell neoplasm that shows M protein in serum or urine

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19
Q

What are the diagnostic criteria of MGUS?

A

M component less than myeloma levels; marrow plasmacytosis

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20
Q

Tumor cells in HL express ____ and ____ but lack ____.

A

CD30, CD15; CD45

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21
Q

What does FL stand for?

A

follicular lymphoma

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22
Q

Where do 75% of all extraosseous plasmacytomas appear?

A

upper respiratory tract, including nasal passages, sinuses, oropharynx, and larynx

23
Q

What is found in the 2a lymphoid follicle’s mantle zone?

A

small cells that surround the germinal center

24
Q

What is the average age of diagnosis of MCL?

A

60yo

25
Q

Most plasma cell neoplasms originate as ____, but can occasionally present as ____.

A

bone marrow tumors; extramedullary sites

27
Q

Most cases of FL have translocations of _____, which places BCL2 under the influence of the IGH promotor.

A

(14;18)

28
Q

BL is endemic in the malarial belt of Africa, where the average age is _____ and involves the jaw or abdomen.

A

4-7yo

29
Q

What are the Igs found in plasma cell neoplasms?

A

IgM (55%), IgA (20%)

30
Q

____ is a B-cell marker that highlights mantle zone and germinal center B-cells.

A

CD20

31
Q

What do the lymph node sinuses contain?

A

lymphocytes, plasma cells, and histiocytes- usually patent

31
Q

Translocations of the MYC oncogene on chromosome 8 at band ____ are a constant feature of Burkitt’s Lymphoma.

A

8q24

32
Q

_____ is highly aggressive but is potentially curable with aggressive therapy.

A

BL

34
Q

What is FL?

A

lymphoma of germinal center B cells (centrocytes and centroblasts)

35
Q

What cells are in the dark zone of the germinal center of a lymph node?

A

centroblasts

35
Q

In ____, the malignant cells usually represent a small minority and contain Reed-Sternberg cells among inflammation.

A

Classical Hodgkin’s Lymphoma (CHL)

35
Q

What is the most frequent type of CHL?

A

nodular sclerosis CHL (NSHL)

36
Q

Most cases of BL have the _____ translocation, which juxtaposes the MYC gene.

A

t(8;14)

37
Q

What is the lymph node cortex?

A

where the follicles and paracortex are

39
Q

Translocations of the MYC oncogene on chromosome 8 at band 8q24 are a constant feature of ____.

A

Burkitt’s Lymphoma

41
Q

In BL, the B-cells express ____ and ____ but are negative for ____, _____, _____, and ____.

A

CD19, CD20; BCL2, CD5, CD23, TdT

42
Q

What is the least frequent subtype of CHL?

A

lymphocyte depleted CHL

43
Q

What are the diagnostic criteria of solitary plasmacytoma of bone?

A

single bone lesions consisting of monoclonal plasma cells; absent of low serum or urine M protein

45
Q

Afferent means ____.

A

towards

47
Q

What cells are found in the lymph node medulla?

A

lymphocytes, plasma cells, macrophages, dendritic cells

48
Q

What is extraosseous plasmacytoma?

A

localized plasma cell tumors that arise outside of the bone marrow

49
Q

Translocations of the MYC oncogene on _____ at band 8q24 are a constant feature of Burkitt’s Lymphoma.

A

chromosome 8

50
Q

Where does NSHL frequently present?

A

above the diaphragm

52
Q

What is the lymph node capsule?

A

thin, fibrous outer covering

53
Q

What does MGUS stand for?

A

Monoclonal Gammopathy of Undetermined Significance

54
Q

CD3 is a _____ marker that highlights abundant ____ in the paracortex and scatter ____ in the germinal center.

A

T-cell x3

55
Q

CD20 is a ____ marker that highlights mantle zone and germinal center ____.

A

B-cell; B-cells

56
Q

What is a plasma cell neoplasm?

A

clonal proliferation of immunoglobulin-producing plasma cells that secrete a single class of Ig, which is usually detectable as an M protein

57
Q

What does MCL stand for?

A

mantle cell lymphoma

57
Q

In contrast to other _____ that are usually indolent, MCL is moderately aggressive.

A

B-cell lymphomas

60
Q

What does BL stand for?

A

Burkitt’s Lymphoma

61
Q

_____ is an indolent malignancy with popcorn or lymphocyte-predominant cells and reactive lymphocytes and histiocytes.

A

nodular lymphocyte-predominant Hodgkin’s Lymphoma (NLPHL)

62
Q

What are the 2 main subtypes of Hodgkin Lymphoma?

A
  1. nodular lymphocyte-predominant Hodgkin’s Lymphoma (NLPHL) 2. Classical Hodgkin’s Lymphoma (CHL)
63
Q

What cells reside in the lymph node paracortex?

A

T-cells

64
Q

What cells are in the light zone of the germinal center of a lymph node?

A

mixed centrocytes, T-cells, dendritic cells, and histiocytes

65
Q

In contrast to other B-cell lymphomas that are usually indolent, ____ is moderately aggressive.

A

MCL

Lindsey's Blood and Lymph Unit III (10 decks)

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