Immunopathology Type 1, Allergies Flashcards

1
Q

What fights parasites in the body?

A

Th2, IgE, IgG

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2
Q

What is IgG’s role in fighting worms?

A

binds the worm or ova and activates complement

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3
Q

What happens when neutrophils respond to the opsonized worms?

A

nothing- they lack a helminthocidal mechanism

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4
Q

How are mast cells activate by worms?

A

worms secrete antigen that diffuse to the mast cells, activating them

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5
Q

How does mast cell degranulation help fight worms?

A

histamine causes smooth muscle contraction; violent peristalsis expels the worms

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6
Q

What do mast cells secrete to attract eos?

A

prostaglandins and leukotrienes

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7
Q

Why do mast cells secrete prostaglandins and leukotrienes?

A

to attract eos

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8
Q

What happens when an eosinophil engages an IgG opsonized worm?

A

it releases its granules, including Major Basic Protein

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9
Q

What is Major Basic Protein?

A

a granule secreted by eos that is highly toxic to helminths

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10
Q

What is the Th2’s role in worm fighting?

A

it attracts both eos and macs and secretes IL-4, 5, and 13 to convert the macs to M2 macs

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11
Q

Why do Th2 cells convert macs into M2 macs in worm infections?

A

to heal damage and wall off the worm

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12
Q

____ binds strongly to the FceR1 receptors on mast cells.

A

IgE

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13
Q

IgE binds strongly to the _____ on mast cells.

A

FceR1 receptors

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14
Q

IgE binds strongly to the FceR1 receptors on ____.

A

mast cells

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15
Q

When _____ are cross linked by an allergen, the mast cell degranulates.

A

2 adjacent bound IgE molecules

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16
Q

When 2 adjacent bound IgE molecules are cross linked by an allergen, _____.

A

the mast cell degranulates