Introduction to Hematologic Malignancies Flashcards
What is a disease of myeloid cells or precursors that is a solid mass?
extramedullary myeloid tumor aka granulocytic sarcoma
Which viruses are known to play a role in lymphoma genesis?
- Epstein-Barr 2. human T cell leukemia virus-1 3. Kaposi sarcoma herpesvirus/human herpesvirus-8
What is grade?
the aggressiveness; rate of growth
Hematologic malignancies are divided into ____ or ____, where acute is used to describe the former and chronic for the latter.
high grade; low grade
Human T cell leukemia virus-1 (HTLV-1) can cause ____.
adult T cell leukemia/lymphoma (ATLL)
A _____ presents as a rapidly enlarging mass.
high grade lymphoma
_____ arise from B cell, T cell, or NK cell lineages.
Lymphoid malignancies
Kaposi sarcoma herpesvirus/human herpesvirus-8 can cause _____.
primary effusion lymphomas
_____ arise from granulocytic, monocytic, erythroid, megakaryocytic, and mast cell lineages.
Myeloid malignancies
Myeloid malignancies arise from ____, _____, _____, ____, and _____ lineages.
granulocytic, monocytic, erythroid, megakaryocytic, mast cell
What is mantle cell lymphoma?
lymphoma defined by t(11;14) involving IGH and CCND1 genes
What is CHL?
classical Hodgkin lymphoma; derived from B-cells, driven by Hodgkin-Reed-Sternberg (HRS) cells
extramedullary myeloid tumor
myeloid cells or precursors; solid mass
____ can cause primary effusion lymphomas.
Kaposi sarcoma herpesvirus/human herpesvirus-8
Hematologic malignancies are divided into high grade or low grade, where ____ is used to describe the former and ____ for the latter.
acute; chronic
another name for extramedullary myeloid tumor?
granulocytic sarcoma
____ has been known to cause classical Hodgkin lymphoma, some cases of Burkitt lymphoma, and some B-cell non-Hodgkin lymphoma.
Epstein-Barr virus