Immunopathology Type 3, Immune Complex Disease Flashcards
____ and ____ attract neutrophils, which release cathepsin G, elastase, and hydrogen peroxide, causing degradation of the BM.
C3a; C5a
What are the treatments of Type 3 immunopathologies?
anti-inflammatory drugs, immunosuppressants, antihistamines, plasmapheresis
What is post-strep glomerulonephritis?
immune complexes in the kidney 10-14 days after a strep infection
What is Hypersensitivity Pneumonitis?
actinomycetes bacteria exposure causes development of IgG antibodies; on 2nd exposure, antigen/antibody complexes form in the lungs
How large is IgM?
750,000 daltons
What pathology of SLE makes it a type 3 disease?
pt makes IgG antibody to ds DNA; immune complexes deposit in the kidneys
What is the reticuloendothelial system (RES)?
all the macs/phagocytes of the tissues
As anaphylatoxins, C3a and C5a release ____ and other mediators from mast cells, increasing the inflammatory rxn.
histamine
What cells cause the symptoms of Hypersensitivity Pneumonitis?
neutrophils and complement initially; Th1 and Th2 in chronic cases
What pathology of RA makes it a type 3 disease?
an IgM autoantibody to one’s own IgG
What is the Arthus reaction?
immune complex formation from booster immunizations- activates complement and neutrophils; causes soreness at injection site
As anaphylatoxins, ___ and ____ release histamine and other mediators from mast cells, increasing the inflammatory rxn.
C3a; C5a
What is an immune complex formation from booster immunizations that activates complement and neutrophils; causes soreness at injection site?
the Arthus reaction
How do immunocomplexes activate complement?
they bind C1q to initiate the classical cascade
As anaphylatoxins, C3a and C5a release histamine and other mediators from ____, increasing the inflammatory rxn.
mast cells
What disease is caused by actinomycetes bacteria exposure causing development of IgG antibodies; on 2nd exposure, antigen/antibody complexes form in the lungs?
Hypersensitivity Pneumonitis
How is the risk of serum sickness minimized?
by affinity purification and by cutting off the Fc portion of the protein and only using the F(ab) or F(ab2)
How can you test for the presence of immune complexes?
- total hemolytic complement will be low; check lysis of RBCs using pts serum as compared to a standard 2. bind serum to complement C1q to look for complex agglutination 3. check for RF by adding pt’s serum to IgG coated microbeads 4. perform a renal biopsy, immunotag, and look for lumpy bumpy appearance
What is serum sickness?
the binding of antibody to exogenous serum, forming immune complexes that accumulate until large enough that the RES can clear it out
C3a and C5a attract _____, which release cathepsin G, elastase, and hydrogen peroxide, causing degradation of the BM.
neutrophils
What is IgA nephropathy?
deposition of IgA and IgG bound to IgA1 in the renal glomerulus
What size immunocomplex can activate complement but is too small to be removed by the RES?
1 million daltons
Name 6 places immune complexes can lodge.
- joints 2. pleura 3. peritoneum 4. skin 5. choroid plexus 6. kidneys
C3a and C5a attract neutrophils, which release ____, ____, and ____, causing degradation of the BM.
cathepsin G, elastase, and hydrogen peroxide
What does RES stand for?
reticuloendothelial system
What is a type 3 immunopathology?
immune complexes get stuck in basement membranes
