Overview

Question 1

What is an infection?

Answer 1

Invasion of host tissues by microorganisms

Question 2

How do microorganisms cause disease?

Answer 2

Host response
Microbial multiplication
Toxins

Question 3

What kinds of exotoxins are there?

Answer 3

Cytolytic
AB toxins
Superantigens
Enzymes

Question 4

What determines whether a pathogen will successfully infect a patient?

Answer 4

Antimicrobial resistance
Virulence factors
Inoculum size

Question 5

What determines whether a patient will be infected?

Answer 5

Co morbidities

Site of infection

Question 6

How do we know if patients have an infection?

Answer 6

History- focal/ systemic, severity, duration, potential exposures

Examination- organ dysfunction

Investigation-supportive- bacteriology, FBC, blood chemistry, imaging, virology

Question 7

How do people get infections?

Answer 7

Source intemediary patient

Person to person transmission

Source to patient

Skin commensals in wrong place

Vertical transmission

Horizontal transmission