Genital Tract Infections Flashcards
What is genital herpes?
A painful, vesicualting infection of external genitalia and lower genital tract caused by herpes simplex virus I and II.
What is the pathophysiology of herpes infection?
Herpes simplex virus infects squamous epithelium and forms an intranuclear inclusion body. Epithelial cells then form giant cells or lyse. Oedema develops locally and causes vesicle formation. These will eventually crust over or become ulcerated.
What are the major symptoms of herpes infection?
Painful ulcers
Fever
Myalgia
Painful urethritis
How is herpes infection diagnosed?
Clinical diagnosis or PCR
How is herpes treated?
Acyclovir - must be given continually to prevent attacks.
What are genital warts?
External genital or perianal papillomata caused by HPV.
Why should genital warts not be ignored?
They are regarded as a precursor to carcinoma of the cervix.
Which HPV viruses cause cervical carcinoma?
Types 16 and 18
How are genital warts treated?
Trichloroacetic acid solution is used which is cytotoxic
Abstain from intercourse
Ask sexual partner to seek treatment.
Which microorganism causes syphilis?
Treponema pallidum. This is a spiral bacterium known as a spirochaete.
When does syphilis develop after infection?
Can develop up to 1 year after infection and has primary, secondary and latent stages.
How is syphilis diagnosed?
It produces painless ulcers or chancres
How is syphilis treated?
A single IM dose of benzathine penicillin and then follow up serology at1,3,6 and 12 months.
Contact tracing
Notifiable disease
What are the most common causes of urethral discharge in males?
N.gonnorhoea or chlamydia trachomatis.
How is urethral discharge in males diagnosed?
Microscopy, culture and antigen detection.
N gonorrhoea will show up as gram negative diplococcus.
PCR tests can be used to detect both C.trochomatis and N.gonorrhoea.