Adaptive Immunity Flashcards
Which MHC molecules present antigens from intracellular microbes?
Like mate we are definitely rthose really annoying people in the library who chat and are clearly in love :P
Definitely
There are many elephants in this room
(MHC class I molecules)
Which T cells recognise MHC class I ?
CD8+
Which MHC molecules recognise antigens from extracellular microbes?
MHC class II
Which T cells recognise MHC class II?
CD4+
What does a naive CD4+ T cell differentiate into?
TH1
TH2
TH17
What do TH1 T cells do?
Activate CD8+ cells into cytotoxic T lymphocytes
By action of IFNg- stimulate B cells to produce antibodies and macrophages to kill opsonized microbes
What do TH2 T cells do?
Activate:
Eosinophils- killing of parasites
B cells- antibody
Mast cells- local inflammation, allergies
What do TH17 T cells do?
Attract neutrophils
What is a slow progressor in HLA typing for HIV response?
Their MHC molecules present key survival peptides for virus survival so they have an effective T cell response
What are the features of MHC class I and class II molecule structure?
Peptide binding cleft- variable region with highly polymorphic residues
Broad specificity- many peptides presented by same MHC molecule
Responsive T cells
What is isotype switching?
Where igM is the main antibody expressed in the primary response which is then overtaken by expression of igG
What does igM do?
Complement activation
What does igE do?
Immunity against helminths, mast cell degranulation (allergies)
What does igG do?
Fc dependent phagocytosis
Complement activation
Neonatal immunity
Toxin/ virus neutralization
What does igA do?
Mucosal immunity
