Ovarian Hyperstimulation Syndrome

Question 1

What is it?

Answer 1

A complication seen in some forms of infertility treatment (rarely occurs sporadically)
- thought that the presence of multiple luteinized cysts within the ovaries results in high levels of not only oestrogen sand progesterone but also vasoactive substances e.g VEGF - results in increased membrane permeability and loss of fluid into intravascular compartment

Question 2

Following what treatment is it more likely to be seen following?

Answer 2

Gonadotropin or hCG treatment

Can be seen with clomifene

Question 3

What symptoms are associated with mild disease?

Answer 3

Abdominal pain

Abdominal bloating

Question 4

What symptoms are associated with moderate disease?

Answer 4

Abdominal pain
Abdominal bloating
Nausea and vomiting
US evidence of ascites

Question 5

What symptoms are associated with severe disease?

Answer 5

Same as for moderate plus:
Oliguria
Haematocrit >45%
Hypoproteinaemia

Question 6

What signifies critical disease?

Answer 6

Thromboembolism
ARD
Anuria
Tense ascites