Folic Acid Flashcards

1
Q

Folic acid is important in the prevention of…

A

Neural tube defects

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2
Q

What is the standard dose that all women should take?

A

0.4mg a day pre conception to 13 weeks

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3
Q

Why should folic acid be taken pre conception?

A

The neural tube is formed within the first 28 days of development, any defect may be present if a woman waits until missed period

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4
Q

Certain women are at an increased risk of neural tube defects such as..

A
Previous child with NTD, FH of NTDs
DM
AEDs
Obese
HIV positive taking co-trimoxazole 
Sickle cell, thalassaemia trait 
Coeliac disease
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5
Q

What can cause folic acid deficiency?

A

Phenytoin
Methotrexate
Pregnancy
Alcohol excess

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6
Q

A woman with risk factors for NTDs should take an increased dose of…

A

5mg from before conception until 12th week

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7
Q

What is folic acid converted to?

A

Tetrahydrofolate - plays a key role in the transfer of 1-carbon units to the essential substrates involved in DNA and RNA synthesis

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