Ovarian cancer

Question 1

what is average survival rate for ovarian cancer?

Answer 1

5 year survival 30%

Question 2

what genes are associated with high risk of ovarian cancer?

Answer 2

HNPCC/Lynch type 11 familial cancer syndrome
BRCA 1
BRCA 2

Question 3

what is the presentation of ovarian cancer?

Answer 3

vague!

indigestion, early satiety, poor appetite
altered bowel habit, discomfort, weight gain
pelvic mass

Question 4

what investigations would you carry out to diagnose ovarian cancer?

Answer 4

USS abdomen and pelvis
CT scan
CA 125
Surgical laparotomy - pathology for definitive diagnosis

Question 5

what is the tumour marker for ovarian cancer?

Answer 5

CA 125

Question 6

what cancers are related to CA 125?

Answer 6

ovarian
colon
pancreas
breast

Question 7

what benign conditions are related to CA 125?

Answer 7

menstruation
endometriosis
pelvic inflammatory disease
liver disease
effusions

Question 8

what type of ovarian cancer does CA 125 detect?

Answer 8

epithelial ovarian tumours

Question 9

what staging is used for ovarian cancer?

Answer 9

FIGO staging

Question 10

what is the cure rates for stages 1-4 ovarian cancer?

Answer 10

stage 1: 85%
stage 2: 47%
stage 3: 15%
stage 4: 10%

Question 11

where does ovarian cancer develop from?

Answer 11

most originate from fallopian tubes

some from pre-existing benign ovarian cysts

Question 12

what are the treatment options for ovarian cancer?

Answer 12

surgery - laparotomy

chemotherapy - taxane and platinum

Question 13

what high risk groups are screened for ovarian cancer?

Answer 13

cancer gene mutation carriers i.e. BRCA 1 and BRCA 2 & HNPCC
2 or more relatives