Others: Anat Flashcards
What comprises malphigian corpuscles
Glomerulus + bowman’s capsule
Aka renal corpuscles
Location of thyroid gland
BELOW thyroid cartilage
AT THE LEVEL of cricoid cartilage
C4/C5
Adrenal cortex zones and what they primarily secrete
Zona glomerulosa (aldosterone -mineralocorticoids)
Zona fasiculata (cortisol -glucocorticoids)
Zona reticularis (androgens)
Drainage thru the superior vena cava
Hemiazygos vein, lumbar vein -> 1. azygos vein
2. Brachiocephalic veins
Drainage thru the inferior vena cava
Common iliac (External + internal)
Hepatic vein (hepatic portal vein: superior and inferior mesenteric + splenic vein)
Celiac artery consists of
Left gastric artery (stomach+ lower esophagus)
Common hepatic a (stomach, duodenum, liver)
Splenic a (spleen)
Major supply to the lower limbs
Femoral artery (external iliac)
Supplies the pelvic contents, bladder, lower rectum, uterus, vagina, prostate, penis, vas deferens
Internal iliac artery
Gonadal artery supplies ovaries and testes
Nasolacrimal duct opens into??
Inferior meatus
Location of hiatus semilunaris
Middle meatus
Level at which pharynx becomes the esophagus
C6
Pharynx extends to the LOWER border of cricoid cartilage
Muscular coat of pharynx
Superior, middle inferior constrictors (X)
Stylopharyngeus (IX) palatopharyngeus (X), salphingopharyngeus (X)
Pharyngeal plexus: IX X XI
Innervation of laryngeal muscles
Recurrent laryngeal nerve (X) “arytenoids”
Except CRICOTHYROID (superior laryngeal nerve)
Abducts vocal cords
Posterior cricoarytenoids -recurrent L.N (X)
Adducts vocal cords
Oblique and transverse arytenoids -recurrent L.N (X)
Increases pitch
Cricothyroid -superior L.N (X)
Tenses and elongates
Decreases pitch
Thyroarytenoid - recurrent (X)
Shortens vocal cords and reduces tension
Wear and tear pigment
Lipofuscin -prominent in old or aging tissues
Lining of loop of Henle
Simple squamous
Lining of thyroid follicle walls
Simple Cuboidal
Lining of ducts of glands
Simple cuboidal
Lining of the gallbladder and intestinal epithelium
Nonciliated simple columnar
Linings of female reproductive tract
Ciliated simple columnar
Lining of oral mucosa
Stratified squamous
Lining of esophagus and vaginal linings
Stratified squamous
Lining of Wall of sweat gland duct
Stratified cuboidal
Lining: Ducts of large glands/parotid gland
Stratified columnar
Lining of upper respiratory tract
Pseudostratified columnar ciliated
Lining of parotid and pituitary gland
Glandular
Where can you find Wharton’s jelly
Umbilical cord; jelly like ground substance
What do mast cells release
Heparin and histamine like basophils
Location of SA node
Crista terminalis
Location of hyoid bone
C3
Meninges from inner to outer
Pia, arachnoid, dura mater
Greater splanchnic nerve para/sympathetic? From what spinal nerves
Both. Sympathetic to abdominal viscera
Parasympathetic to pelvic
All splanchnic nerves are sympathtic. May para lang for pelvic ang greater
*Greater splanchnic nerve: T5-T9
*Lesser splanchnic nerve: T10-T11
*Least splanchnic nerve: T12
*LUMBAR: L1-L3
Portal system
Superior mesenteric
Inferior mesenteric (often drains into splenic)
Splenic vein
Has no valves!!
Surveillance cell of the pulp (connective tissue)
Histiocytes
-tissue macrophage
Macrophage in granuloma (ex. TB)
Epitheloid cells and langhans giant cells
Prevents transmission of pathogens from mother to fetus
Hofbauer cells (found in placenta)
macrophage in the liver?
macrophage in the CNS?
kupffer
microglia
macrophage in the pulmonary alveoli of lungs?
macrophage of lymph nodes?
dust cells/alveolar macrophage (heart-failure cells)
sinus histiocytes
antigen presenting cell of spleen
dendritic cells. not only spleen pati lymph nodes
location of primary absorption of iron
duodenum
lymphatic ducts carry lymph at the?
junction of IJV and subclavian vein
Layer of epidermis: cells are undergoing apoptosis
S. Granulosum
Layer of epidermis: most numerous layer of keratinocytes
S. Corneum
Layer of epidermis: only found in thick skin
S. Lucidum
Layer of epidermis: cessation of Tonofilament production; assembly of keratin
S. Granulosum
other name for maxillary sinus
antrum of highmore
meckel’s cartilage is the framework of?
mandible
main body transforms into malleus and incus
Pharyngeal arch and cartilage of stapes
2nd, reichert’s cartilage
activates vitamin D
kidney
produced by skin, converted into inactive by liver, activated by kidney
reflex center for visual activities
midbrain
respiratory centers in the brain
medulla
pons
Lining of the respiratory system from nasal cavity to alveoli
Nasal cavity - respiratory epi
Nasopharynx - respi (40%), nasopharyngeal epi (60%)
Oropharynx - nasopharyngeal epi
Larynx - respi epi
Trachea - respi epi
Bronchi - respi epi
Bronchioles - ciliated cuboidal epi w/ clara cells
Alveoli - simple squamous
*Respi: pseudostratified columnar ciliated with goblet cells
Nasopha: startified squamous
Part of respiratory tract without cartilage? Without goblet cells?
Without cartilage - bronchioles
Without goblet cells - terminal bronchioles
Predominant cell in alveoli
Type I pneumocyte - squamous
-cannot multiply
-gas exchange
*Type II pneumocyte (cuboidal) is supporting. Decreases surface tension, can multiply and replace type I
Site for coniotomy or emergency tracheotomy?
Aka as cricothyrotomy
Cricothyroid ligament
Boundaries of isthmus of the fauces
Anterior pillar - palatoglossus (X)
Posterior pillar - palatopharyngeus (X)
*Contains the palatine tonsils
Cells of the stomach, what it secretes and its function?
1. Mucous neck cells - mucous (alkaline to protect from acid)
2. Parietal or oxyntic cells
2.1 gastric acid (HCl) - digestion, activate pepsinogen
2.2 intrinsic factor -regulate absorption of vit b12 in the ileum
2.3 gastroferrin - iron absorption in duodenum
3. G cells - gastrin- produce gastric acid by stimulating parietal cells
4. Chief cells - pepsinogen
Funnel like opening of nasal cavity into the nasopharynx
Choanae
bone that contributes to neurocranium AND facial skeleton
ethmoid and sphenoid
Glands in the intestines, location and function
Brunner’s gland (duodenum) - secretes alkaline mucus
Goblet cells (small and large intestines) - mucous
Crypts of Liberkuhn/intestinal gland (small intestines) - contain enteroendocrine cells
divides the liver into anatomic right and left lobe
falciform ligament
*ligament teres - remnant of umbilical vein
Specialized non encapsulated tonsils found in the submucosal ileum
Peyer’s patches
Preferred site for vit B12 absorption? Iron?
Iron - duodenun
B12 - ileum;
remember gastric parietal cells secrete intrinsic factor
Plicae circulares is majorly found in the??
Jejunum
P.c. aka valves of Kerckring
Where can you find crypts of Liberkuhn? contains what?
Small intestines
Intestinal gland /tubular gland
Contains paneth cells (secrete antibacterial enzyme) and endoendocrine cells
Can be found in the submucosa of duodenum
brunner’s gland - maintain alkalinity
Where can you find cholesterol stones? (Choledocholithiasis)
Gall bladder, cystic duct
*Remember gallbladder does not have submucosa but with rugae
Ampulla of vater is? Found in?
Hepatopancreatic ampulla
Wirsung + common bile duct
Found in pancreas exits to duodenum
*Sphincter of Oddi
*Duodenal papilla
Part of large intestine without taenia coli (3 bands of longitudinal muscle)
Rectum
Parts: cecum, colon, rectum
What divides the liver into anatomic right and left lobes?
It attaches the liver to the anterior abdominal wall.
Falciform ligament
*coronary ligament attaches it to the diaphragm
What is the ligamentum teres?
Found within the falciform ligament and it was the fetal umbilical vein
Differentiate greater omentum and lesser omentum
Greater: greater curvature of stomach + transverse colon (gastrocolic ligament)
lesser: lesser curvature of stomach, duodenum, liver
Cells found on the surface of tonsils that trap microbes
M cells
Differentiate serosa and adventitia
Serosa - intraperitoneal, epithelium
Adventitia - retroperitoneal, connective tissue
**Mucosa (inner), submucosa, muscularis, adventitia/serosa
What is the space of disse? Location?
aka perisinusoidal space
Space between hepatic sinusoids (capillary with pores) and hepatocytes.
in the space, stellate cells can be found
*Liver
Pancreatic enzymes produced by acinar cells
- Pancreatic lipase - breaks down fat
- Amylase - starch
- Trypsinogen/Tripsin - protein
How is bile produced?
RBC dies
Hemoglobin
Heme + globin
Porphyrin (red) + iron
Biliverdin (green)
Unconjugated bilirubin (yellow-green)
LIVER
conjugated bilirubin (can be stored gallbladder as part of bile)
Duodenum *intestinal bacteria
CB
Unconjugated B
Urobilinogen -> urobilin (yellow) in kidneys
Stercobilin (brown) -> large intestines
Enteroendocrine cells secretion
G cells - gastrin
I cells - CKK
Enterochromaffin cells - serotonin (intestinal motility) and histamine (gastric acid secretion)
S cells - secretin
K cells - GIP
K, SIGE!
Pacemaker of stomach
Interstitial cells of cajal (enteric nervous system)
Pathway of sperm
- Seminiferous tubules of testis (spermatogenesis)
- Epididymis (maturation of sperm)
- Vas deferens (from testis to urethra)
- Ejaculatory duct (vas def + seminal vesicle)
- Urethra (urine and sperm)
- Penis
Forms blood testis barrier? Blood brain barrier? Blood csf barrier?
Sertoli cells (gives nutrients to spermatogonium)
Astrocytes
Ependymal cells (produces csf)
Responsible for wrinkled appearance of scrotum
Dartos muscle
*Scrotum is fibromuscular -dartos muscle and -cremaster (cremasteric reflex -regulates temp of testis)
Muscle for erection and ejaculation
Bulbospongiosus muscle
Muscle that ejects urine from bladder
Detrussor muscle
Counterpart of cowper’s gland in females
Bartholin’s gland -moistens the female reproductive organ
*bartholin’s gland is also known as bulbourethral gland w/c is responsible for pre-ejaculation
CT capsule that surrounds the testes
Tunica albuginea
Glands of the male reproductive organ
Prostate gland (PSA, acid phosphatase)
Seminal vesicle (semen)
Cowper’s gland / bulbourethral glands (pre-ejaculation)
Erectile tissues
Corpus cavernosum - side
Corpus spongiosum - front (keep urethra open)
Differentiate prostatic, membranous, spongy/penile urethra
P - widest, most dilatable
m - shortest, least dilatable
S - longest, narrowest, where Cowper’s gland open into
Where is the main gland of prostate gland located?
Peripheral zone
Center zone is periurethral gland
Prostatic secretion makes up 25% of semen
Mammary gland is what type of gland?
Compound tubuloalveolar gland
Where is ovum fertilized?
Ampulla of fallopian tube
Parts of fallopian tube:
1. Fimbrae
2. Infundibulum
3. Ampulla
4. Isthmus
*Egg is only viable for 24 hrs
Surrounds alveoli; contracts to expel milk
Myoepithelial cells
Lactiferous ducts - excretory duct that emerge in the nipples
Ligament that supports breast
Suspensory ligament / Cooper’s ligament
Broad ligament and stroma supports ovaries
3 layers of uterus
Perimetrium
Myometrium - smooth muscle (responds to oxytocin)
Endometrium - site of implantation (responds to progesterone and estrogen)
Macrophage of kidney
Mesangial cells
Pathway of filtration in a nephron
Afferent BV
(Thru podocytes)
Glomerulus
PCT
Loop of henle
DCT
Collecting ducts
Minor calyx
Major calyx
Renal pelvis
Lining of kidney
Renal tubules- Simple cuboidal epithelium
Bowman’s capsule- simple squamous
Filtering unit of the glomerulus
Podocytes (RBC cannot pass)
Nephron is the filtering unit of the kidney
Vessels adjacent to renal tubules
Vasa recta
2/3 of filtrate are reabsorbed here
PCT via active transport and facilitated diffusion (aquaporins)
Renal tubule with counter current mechanism
Loop of henle
1. Descending segment = concentrating segment, semi-permeable (water out)
2. Ascending segment = diluting segment, not permeable (Na, Cl, K goes out via ion pumps)
Explain tubuloglomerular feedback
Macula densa in DCT detects NaCl concentration.
High = afferent arterioles to constrict,
Low = aa to dilate and juxtaglomerular cells to release renin –> aldosterone (reuptake Na, inc BP)
Urinary bladder epithelium
Transitional epithelium
Relaxed: cuboidal
Stretched: squamous
organelle used by wbc to move across endothelium
pseudopods
organelle used by wbc to move across endothelium
pseudopods
phenomenon through which blood borne antigens are attracted and fixed to areas of inflammation?
anachoresis
explain humoral immunity
mediated primarily by b cells
antigen is engulfed by APC (B cells) — presents the digested antigen (MHC2) — T-helper/CD4 recognizes MHC2 and binds — CD4 releases cytokines to alarms other WBCs and activates B-lymphocytes — B cells transforms to memory B cell and plasma cell which will produce antibodies
Ag-Ab complex will activate complement system
— c3b binds ti Fc receptor of antibody (opsonization) — destruction of antigen by phagocytosis or enzymes *some can resist — Membrane attack complex (C5b, c6, c7, c8, c9)
explain cell-mediated immunity
mediated by t cells
prevent spread at a cellular level
infected/cancer cell presents antigen (MHC1) — CD4 binds — Cd8 activation — cd8 binds to cell with mhc1 — cell is destroyed
mediator of the different hypersensitivity types
type 1 Allergic = IgE
type 2 Cytotoxic hyper = IgM/IgG
type 3 Immune complex hypersensitivity = antigen and antibody complex accumulation
type 4 Delayed = immune cells (T-cells)
differentiate the 3 cell types according to regenerative property
labile - multiplies throughout life, short life
stable cell - multiplies when damaged
permanent cell - cannot multiply
types of cellular degeneration
- cloud swelling
- hydropic or vacuolar
- fatty degeneration
- hyaline degeneration
- necrosis
hyaline accumulation in glomerulus resulting to sclerosis and associated with diabetes (2 names)
diabetic glomerulosclerosis / Kimmel Stiel-Wilson syndrome
types of necrosis
- coagulation necrosis (architecture is preserved, proteins are denatured)(all tissues: heart>brain)
- liquefaction necrosis (brain)
- caseous necrosis (pulmonary tb) - cheese like
- gummatous necrosis (tertiary syphilis) - gumma or soft granulomatous growth
- gangrenous (diabetic patients) - loss of blood supply
- fat necrosis (breast ca, pancreas) - fat-calcium complexes accumulation
accumulation of iron in the macrophage
hemosiderin (golden brown or rust)
heart-failure cells
bluish line in marginal gingiva
Burton’s line due to lead poisoning (Plumbism)
silver poisoning is Argyria
extrachromosomal dna within a cell that is separated from its chromosomal dna?
plasmid
binary fission is the cell division of bacteria
types of bacterial recombination
- conjugation - sex pili , must be F factor positive
- transformation - engulfing DNA left by dead bacteria
- transduction - uses bacteriophage or bacterial virus to transfer plasmids
differentiate bacterial cell walls
composed of glycoproteins. gram positive have thick peptidoglycans (murein) layer. gram negative has thin peptidoglycan layer and has outermembrane containing endotoxins (LPS)
acid fast cell wall has MYCOLIC ACID
bacterial staining
gram staining (VIAS)
acid fast staining (CAM) -heat mordant for ziehl nieelssen and tegritol mordant for kinyoun
polysaccharide synthesized from sucrose by bacteria (strep etc) -major component of dental plaque
dextrans and levans (sticky sugar)
function of plasmin?
fibrinolysis / blood clot dissolution
differentiate alpha hemolytic, beta hemolytic and gamma-hemolytic STREP
alpha - uses hydrogen peroxide to lyse cells INcompletely
beta - uses streptolysin to lyse cells COMPLETELY
gamma - does not hemolyse RBC
virulence factors of staphylococcal
protein A -prevent complement action
coagulase -activates prothrombin to thrombin
staphylokinase -activates plasminogen to plasmin
hyaluronidase -breaksdown hyaluronic acid
common virulence factors of streptococcal
streptokinase -plasminogen to plasmin
pneumolysin -s. pneumoniae
M protein -antigen of group A beta hemolytics
Part of cranial bone where optic canal is found
Sphenoid. Between lesser and greater wing
*Greater wing (SOF, IOF, ro2ndum, ovale, spinosum) forms the roof of infratemporal fossa and floor of middle cranial fossa
Roof of sella turcica
Diaphragma sellae
*Sella turcica houses pituitary gland, thus, D.S. covers the gland
Forms left optic tract
Left lateral process + right optic nerve
Function of tegmentum tympani
Bony plate forming the roof of tympanic cavity. Separates the subarachnoid space (csf) and tympanic cavity
DNA replication enzymes
- EnDoNucleAse (cleaves DNA segment)
- Helicase (unzips dna)
- TOpoisomerase / DNA gyrase (prevent excessiveTOrsion)
- DNA primase (RNA primer – leading and lagging strand)
- DNA polymerase (chain elongation, base pairs)
- DNA ligase (bridge gaps in OKAZAKI fragments)
Marks upper limit of true pelvis
Iliopectineal line
Special sensory receptors
Hair cells (organ of corti for sound)
Taste buds
Olfactory neuroepith (schneiderian membrane)
Cones and rods (retina)
Distinctive whorls of degenerative ng epithelial cells in the medulla of thymus
Hassall’s corpuscle
Depolarization wave moves from one node of ranvier to the next
Saltatory conduction
*Unmyelinated = orthrodromic/continuous conduction
When a nerve or muscle does not respond to any stimulus regardless of its strength and frequency
Absolute refractory period
Part of eye where no cones or rods are present (blindspot)
Optic disc
Drainage of aqueous humor
Canal of schlemm
*Aqueous humor- anterior part of eye
*Vitreous humor- posterior part
1st stool of a baby
Meconium
Red stool is aka as?
Black stool?
Red - hematochezia
Black - melena
What type of hypersensitivity reaction is Arthus reaction?
Type III - serum sickness, glomerulonephritis, SLE
*Horse serum is injected to the skin of rabbit
carcinogen in smoked or burned food
benzo-a-pyrenes
carcinogen in smoked or burned food
benzo-a-pyrenes
function of liver in drug metabolism
- lipid soluble to water soluble
- active drugs to inactive form
- prodrugs to active form
Amount of blood pumped by heart per minute
Cardiac output
Stroke volume x heart rate
70ml x 70 bpm = 4900ml/min or 5L/min
Can be 4-7L/min
Factors affecting cardiac output
- ⬆️Contractility = ⬆️stroke volume
- ⬆️Preload = ⬆️stretch = ⬆️force of contraction = ⬆️ stroke volume
*Frank starling law - ⬆️Afterload = ⬇️stroke volume
shunt that allows oxygen to bypass the liver
ductus venosus (fetal) which carries oxygenated blood, it becomes the ligamentum venosus
small blood vessels supplying larger blood vessels
vasa vasorum
vessels with the greatest cross-sectional area
capillaries (aorta has the smallest cross-sectional area)
blood flow is fastest in what blood vessel
aorta (smaller cross sectional area = faster blood flow)
peripheral vascular resistance is greatest in?
arterioles (have high blood pressure; veins have low PVR = highly compliant = stetching property of veins because of thin muscular layer)
*vascular resistance is the resistance of the blood vessel wall against blood pressure
Types of nuclear changes during apoptosis
Pyknosis - nucleus shrinks and chromatin condenses
Karyorrehexis - fragmentation of the nucleus and chromatin disintegrates
Karyolysis - nucleus dissolutiob
Axoneme
9+2 pattern ot 9+0 pattern arrangemrnt of microtubules present in cilia, flagella, tail of sperms
Longest phase of cellular division
Interphase (g1 - cell grows, S - dna replication and rna synthesis, g2 - prepare for mitotis and double organelle)
G0 - no more division
Phenomenon wherein homologous chromosomes pair during meiosis
Synapsis (prophase 1)
Sharing of DNA of two homologous chromosomes
generic recombination or
Crossing-over
Chiastmata formation
(Prophase 1)
no synapsis and recombination sa prophase 2 ha!
Holds the chromosomes during cellular division
Centrosome - contains pair of centrioles made of microtubules arranged in cartwheel pattern
Most important buffer in the blood plasma
Bicarbonate (HCO3-)
Phospate also acts as a buffer
Other term for Macula adherens
Spot weld like*
Desmosomes - attaches same cells
Ex. Epidermis and cardiac muscles
(*For hemidesmosomes, different cells - junctional epith and tooth surface etc)
Forms a bridge that allows ion diffusion between cells
Gap junction
Differentiate tight junctions and adherens junctions
Zona occludens (TJ) prevents leaking of substance
Zona adherens (AJ) prevents separation of epithelial cells during intestinal contraction
Primary buffer in kidney
Ammonia
Three openings of diaphragm
C 8 phrenic (caval)
E 10 vagus (esophageal)
A 12 azygos and thoracic duct (aortic)
Divides pelvis into having greater and lesser sciatic notches
Ischial spine
Ileum - most superior, 4 spines
Ischeum - most posterior and inferior, one spine
Pubis - most anterior
Levator ani muscles
Iliococcygeus muscle
Pubococcygeus muscle
Puborectalis muscle
Responsible for the elasticity of muscles
Titin (largest protein)
Major excitatory neurotransmitter
Glutamate
Major inhibitory neurotransmitters
Gamma amino butyric acid
Location of apex heart beat
5th left intercostal space, midclavicular line
What is the starling’s law of the heart?
The more the cardiac muscle fibers are stretched, the more forcefully they contract
Substances that influence blood pressure
Nitric oxide (endothelium) - vasodilation
Antidiuretic hormone (supraoptic nuclei -water retention - inc blood volume -inc BP
Epi and norepi (adrenal medulla) -inc heart rate, vasoconstriction
Atrial natriuretic peptide (ANP)
-excrete water and Na
Anchors the vocal cords
Arytenoid carilages
Supports the posterior of the tracheal wall
Trachealis muscle
Pores between alveoli present in some alveolar walls
Pores of Kohn
complement protein for chemotaxis of wbc
c5a
complement protein for activation of wbc
c3a
c4a
c5a
complement protein for membrane attack complex
c5bc6c7c8c9
boltes five
Location and Effect of alpha 1 receptor
Vasoconstriction (inc BP)
Decrease blood flow to salivary glands, mucosal membranes, kidneys, and abdominal viscera (decrease function and secretions)
Pupillary dilation (mydriasis)
Closing of sphincters of stomach and urinary bladder
Increased sweating (on palms and soles)
Alpha 2 receptors location and effect
Vasodilation (dec BP)
Beta cells dec insulin secretion
Dec pancreatic acinar cells digestive secretions
Platelet plug formation
Effect of Beta 1 receptors
Inc force of contraction and heart rate
Renin secretion
ADH secretion
Breakdown of triglycerides
Effect of beta 2 receptors
Bronchodilation
Vasodilation (BV in heart, skeletal muscle, adipose tissue, liver)
Glycogenolysis (hepatocytes)
Effect of beta 3 receptor
Thermogenesis (brown adipose tissue)
Principal site of protein digestion?
Stomach (pepsin)
Mediate hyperventilation upon detecting increased arterial PCO2
Medullary chemoreceptors
demarcates the occipital lobe
calcarine fissure
connects the lateral hemispheres of the cerebellum
vermis
separates the cerebrum and cerebellum
tentorium cerebelli
Protective reflex that provides blood flow to the CNS system in response to the increase in intracranial pressure (ex. Due to intracranial hemorrhage)
Cushing’s reflex or vasopressor response
Triad: hypertension, bradycardia, irregular breathing
*Systolic hypertension –> increase pulse pressure
Enzyme that catalyzes CO2 + H2O = H2CO3 reaction
Carbonic anhydrase
Complement system proteins that are also known as Anaphylatoxins
C3a
C5a (chemotaxis)
Anterior tooth most likely to have a bifurcated root
Permanent mandibular canine
Elastic fibers seen in PDL and gingival fibers
Oxytalan - pdl
Elaunin - gingival fibers
Elastic - to regulate blood flow