Other types of diabetes

Question 1

other types

Answer 1

• Gestational: during pregnancy
• Recognised genetic syndromes: MODY – maturity onset diabetes in the young
• Secondary diabetes

Question 2

Causes of gestational diabetes

Answer 2

• Increased insulin resistance
• Associated with FH of diabetes type 2
• Develops in 2nd/3rd trimester
• More common in overweight and inactive
• problems in neonatals: macrosomia (weighs more than 8 pounds on delivery), respiratory distress,neonatal hypoglycemia

Question 3

Causes of secondary diabetes mellitus

Answer 3

• Drug therapy
• Pancreatic dysfunction : CF, haemochromatosis, Chronic pancreatitis
• Genetic syndromes
• Endocrine disorders: Cushing’s, Acromegaly, Phaeochromocytoma

Question 4

MODY characteristic

Answer 4

Autosomal dominant

Single gene defect in either glucokinases or in transcription factor genes

Question 5

Glucokinase mutation

Answer 5

• From birth
• Stable hyperglycemia
• Diet treatment
• Rare complications

Question 6

Transcription mutation factors

Answer 6

• Adolescence
• Progressive hyperglycemia
• 1/3rd DIET
• 1/3rd Oral hypoglycemia agent
• 1/3rd insulin