OTHER MAJOR BLOOD GROUPS Flashcards
1
Q
Working party on terminology for red cell surface antigens ; to facilitate computer storage and retrieval of blood groups information and to help standardize blood group system and antigen names
A
International Society of Blood Transfusion (ISBT)
2
Q
_____digits represent the system, collection or series
A
First three digits
3
Q
____ digits identify the antigen
A
Second three digits
4
Q
Consists of one or more antigens controlled at a single gene locus or by two or more very closely linked homologous genes with little or no observable recombination between them
A
System
5
Q
Are antigens that have a biochemical, serologic, or genetic relationship burn do not meet the criteria for a system
A
Collection
6
Q
Remaining RBC antigens that aren’t associated with a system or collection are catalogued into the _____ series of low prevalence antigens or the ____ series of high-prevalence antigens
A
700 series ; 901 series
7
Q
Total number of blood group system as of 2023 of July
A
45
8
Q
Total number of blood group antigens as of 2023 of July
A
357
9
Q
Blood group collection starts with ISBT number ____
A
200
10
Q
A blood group system ; “Plasma antigen” ; not intrinsic to the red cell ; synthesized by the tissue
A
Lewis system
11
Q
Lewis system : Adsorbed in the RBC membrane
A
Type 1 glycosphingolipids
12
Q
Lewis system : 2 antigens
A
Le^a and Le^b
13
Q
Only the Le gene is present
A
Le^a
14
Q
Le gene, Se gene, and H gene
A
Le^b
15
Q
Lewis gene : Chromosome ___
A
19
16
Q
Gene that codes for the production of fucosyl transferase
A
Le gene
17
Q
Lewis Phenotypes : found in cord blood ,cancer and pregnant woken
A
Le (a-b-)
18
Q
Lewis Phenotypes : present in non secretors
A
Le (a+b-)
19
Q
Lewis Phenotypes : present in secretors
A
Le (a-b+)
20
Q
Lewis system ISBT number
A
007
21
Q
Lewis antibodies must be
A
Naturally occurring - Le (a-b-)
IgM
Neutralizable by the plasma
22
Q
Associated with receptor of H.pylori and Norwalk virus
A
Le^ab
23
Q
Marker for Reedsternberg cells
A
Le^x
24
Q
Lewis antigen : seen in increased renal graft and heart disease and in increased susceptibility to to infection by Candida and uropathogenic E.coli
A
Le (a-b-)
25
Anti-Le^b : reacts best when both the Le^b and H antigens are present
Anti-Le^bH
26
Anti-Le^b : recognizes any Le^b antigen regardless of the ABO type
Anti-Le^bL
27
Most commonly detected Lewis antibody
Anti-Le^a
28
Related antigens to P1PK (003 )
P1, PK, NOR
29
Related antigens to Globoside (028)
P, PX2
30
Related antigens to Globoside collection (209)
LKE
31
Most common phenotypes of P blood group
P1 and P2
32
Poorly expressed at both and may take up to 7 years to e fully expressed
P1 antigen
33
P blood group antibody : naturally occurring IgM (P1-) ; found in patient with Echinococcus and Fasciola
Anti-P1
34
P blood group antibody : first described in the serum of Mrs. Jay, a “p” individual with adenocarcinoma of the stomach ; increased incidence of spontaneous abortion : IgG or IgM - SLE
Anti-PP1K (formerly Anti-Tja)
35
P blood group antibody : associated with habitual early abortion
Alloanti-P
36
P blood group antibody : cold reactive IgG autoantibody (Biphasic hemolysin) ; Paroxysmal cold hemoglobinuria ; Donath-Landsteiner antibody test - incubated at cold temp (clumping) ; then warmed at 37C (lysis + )
Autoanti-P (Donath-Landsteiner antibody)
37
Anti-P1 sources
Liver flukes
Tapeworms
Earthworms
Pigeon, turtle, doves
38
Phenotypically related to the P blood group system ; a marker of embryonic and mesenchymal stem cells
Luke (LKE) antigen
39
Phenotypically related to the P blood group system ; a marker of embryonic and mesenchymal stem cells
Luke (LKE) antigen
40
Receptor for P-fimbriated uropathogenic E.coli
P system antigen
41
Receptor for parvo virus B19
P antigen
42
Receptor for Shiga toxin and E. Coli - associated with HUS (hemolytic uremic syndrome) ; provides some protection against HIV infection of peripheral blood mononuclear cels ; marker of apoptosis in germinal center B cells, Burkett lymphoma, and lymphoblastic leukemia
P^k antigen
43
I blood group system ISBT NUMBER
027
44
I system : linear antigen
“i”
45
I system : branching antigen
“I”
46
I blood group system (02700) : ____
I blood group collection (207002) : _____
Big “ I “ ; small “ i “
47
I system antibody : associated with cold hemagglutinin disease ; mycoplasma pneumoniae
Anti-I
48
I system antibodies : associated with cold hemagglutinin disease ; mycoplasma pneumoniae
Anti-I
49
I system antibody : associated with infectious mononucleosis
Anti-i
50
Other sources of I and i antigens
Plasma, serum
Saliva
Human milk
Amniotic fluid
Urine
Ovarian cyst fluid
51
Increased ____ antigen is seen in acute leukemia, hypoplastic anemia, megaloblastic anemia, sideroblastic anemia, thalassemia, sickle cell disease, paroxysmal nocturnal hemoglobinuria (PNH), and chronic hemolytic anemia, Chronic dyserythropoietic anemia type Il or hereditary erythroblastic multinuclearity with a positive acidified serum test (HEMPAS)
I antigen
52
M and N antigens are found in
Glycophorin A
53
S/s antigens are found in
Glycophorin B
54
The M and N antigens are differentiated on the ___ and ___ amino acids
1st : M (serine) ; N (leucine)
5th M (glycine) ; N (glutamic)
55
The S/s ntigens are differentiated based on the ___ amino acids
29th amino acid
S : methionine
s : threonine
56
Is the null phenotype in the MNS system
MkMk
57
Serve as the receptor of pyelonephritiogenic stains of E.coli
GPA^M
58
Receptor of plasmodium falciparum
M & N
59
MNS antibody : naturally occurring, IgM ; reacts best at pH 6.5 (Acidic)
Anti-M
60
MNS antibody : seen in renal patients ; IgM
Anti-N^f
61
MNS antibody : seen in renal patients where equipment used is treated with formaldehyde ; IgM
Anti-N^f
62
Destroys MN antigens by adding enzymes, ______ (eluting reagent - to remove bound antibodies)
ZZAP
63
Antigen located on Glycophorin B between amino acid 33 and 39
Universal antigen
64
S-s- = U(?)
U- (universal antigen negative)
65
MNS antibody : IgG in nature
Anti-S/ anti-s
66
First blood group system discovered after the introduction of antiglobulin testing ; identified in the serum of Mrs. KELLER ; found only in RBC
Kell (006)
67
Most common Kell antigen
Small k
68
Rare Kell antigen
Capital K
69
Kell antigen expression is dependent upon the presence of the _____
Kx protein
70
Null Kell phenotype
K0
71
The only antigen in the Kx system
Kx(019)
72
Most common antibody found (Excluding ABO and Rh) ; associated with E. coli 0125:B15 ; IgG in nature (Can cause HDFN)
Anti-K
73
Absence of Kx and Km ; marked depression of ALL other Kell antigens ; associated with Chronic Granulomatous Disease ; male
McLeod phenotype
74
Duffy (008) antigens
Fy^a & Fy^b
75
Destroyed by enzymes ; member of the superfamily of chemokine receptors (DARC)
Duffy (008) system
76
DARC
Duffy Antigen Receptor for Chemokines
77
Duffy (008) system : Resistant from Plasmodium vivax and Plasmodium knowlesi
Fy null
78
The amino acid at position 42 on the Duffy glycoprotein defines the Fya and Fyb polymorphism: Fya has ______, and Fyb has ______
Glycine ; aspartic acid
79
IgG in nature ; associated with HDFN ; demonstrate dosage
Anti-Fya and anti-Fyb
80
Kidd (009) antigens
JKa, JKb, JK3
81
Kidd (009) system function
Urea transport
82
Not easily detected Kidd antibody ; exhibits dosage
Anti-Jka and anti-JKb
83
Kidd (009) system : antibody associated with severe immediate and delayed HTRs and with mild HDFN
Anti-JK3
84
Found n the serum of a patient with LUPUS ERYTHEMATOSUS ; affected by enzyme
Lutheran (005) system
85
Lutheran (005) antigens
Lu^a and Lu^b
86
Lutheran (005) antigens
Lu^a and Lu^b
87
Lutheran (005) antibody : IgG, IgM, IgA in nature
Anti-Lu^a
88
Lutheran (005) antibody : IgG, immune antibody
Antu-Lu^b
89
Lutheran (005) antibody : reacts to all except Lu(a-b-)
Anti-Lu^3
90
Diego (010) system : antigens
Di^a/Di^b , Wr^a/Wr^b, and Wu/DISK
91
Diego (010) system : red cell anion exchanger (AE1) ; solute carrier family-4. Anion exchanger member 1 (SLC4A1 SLC4A1)
BAND 3
92
Marker of Mongoloid ancestry
Dia
93
Diego (010) antibody
Usually IgG
94
Yt (011) system : high prevalence antigen in all populations
Yt^a
95
Yt (011) system : low-prevalence antigen ; not found in Japanese
Yt^b
96
Amino acid substitution on the glycosylphosphatidylinositol (GPI) linked RBC glycoprotein acetylcholinesterase (AChe)
Yt (011) system
97
Yt (011) system : antibodies
Usually IgG (CANT CAUSE HDFN)
98
X chromosome and g for “Grand Rapids”, where the patient was treated ; controlled by X-linked gene ; antigen has a higher prevalence in FEMALES than in males
Xg (012) system
99
Xg (012) system : antigens
Xg^a and CD99 (12E7 and MIC2)
100
Scianna (013) system : High prevalence antigen
Sm (Sc1)
101
Scianna (013) system : low prevalence antigen
Bu^a (Sc2)
102
Sc gene : located in chromosome __ at ____
1 at 1p34
103
Sc gene product
Erythroid Membrane Associated Protien (ERMAP
104
Sc phenotype
Sc1 and Sc2
105
Scianna (013) system : antibody
Anti-Sc3
106
Carried a mono-ADP ribosyltransferase 4 (ART4) attached to the RBC membrane by a GPI anchor
Dombrock (014) system
107
Dombrock (014) antigens ; poor immunogens
Do^a and Do^b
108
Scianna (013) system : highly immunogenic
Gy^a
109
Scianna (013) system : highly immunogenic
Gy^a
110
Colton (015) antigens : high and low prevalence antithetical antigens
Co^a and Co^b respectively
111
Co(a-b-)
Co^3
112
Co(a-b-)
Co^3
113
Carried on an integral membrane protein, aquaporin 1 (AQP1)
Colton antigen
114
A glycoprotein that carries the LW antigens ; a member of the immunoglobulin superfamily
Intracellular adhesion molecule 4 (ICAM-4)
115
Landsteiner-Wiener (016) system : Common in serum from patients with warm autoimmune hemolytic anemia
Autoanti-LW
116
Not Intrinsic to the RBC membrane ; adsorbed in the RBC membrane ; C4 component (C4b & C4a)
Chido/Rodgers (017) System
117
Ch antigens
C4b
118
Rg antigens
C4a
119
Chido/Rodgers (017) antigens
Ch1- Ch6 , Rg1 - Rg2
120
The antigens are carried on sialoglycoprotein structures GPC and GPD - these help maintain the RBC membrane integrity through interaction with protein band 4.1
Gerbich (020) system
121
Type : Yus
Antibody : Anti-Ge2
Gerbich negative phenotypes : ____
Ge: -2 , 3 , 4
122
Type : Gerbich
Antibody : Anti-Ge2 or anti-Ge3
Gerbich negative phenotypes : ____
Ge: -2, -3, 4
123
Type : Leach type
Antibody : Anti-Ge2 or anti-Ge3
Gerbich negative phenotypes : ____
Ge: -2, -3, -4
124
Antigens are carried by the DAF (CD55)
Cromer (021) system
125
Strongly expressed on placental tissue and wil adsorb Cromer antibodies
DAF
126
Antigens are located on complement receptor 1 (CR1)
Knops (022) system
127
Knops (022) system ; represents the serologic null phenotype for the Knops blood group
Hegelson phenotype
128
Indian (024) system : Antigen seen in 4% of Indians , 11% of Iranians, and 12% of Arabs
In^a
129
Indian (023) system is carried in ___
CD44
130
Named after the antibody maker, Mrs. Kobutso ; carried in CD147
Ok (024) system
131
Only antigen in Raphael (025) system ; name is derived from monoclonal, and Eleanor Roosevelt
MER2
132
ISBT : 026
John Milton Hagen system
133
Found on the glycerol transporter aquaporin 3 (AQP3)
The Gill (029) system
134
ISBT : 030
RH-associated Glycoprotein system
135
Was first thought to be a subgroup of A called Apae
Forsmann glycosphingolipid
136
Receptor for pathogens such as E. coli ; in honor of John Forssman
The FORS (031)
137
FORS (031) Antigen
FORS1
138
Jr antigen with high-prevalence in most populations
Jr^a
139
Jr phenotype found more commonly in Japanese
Jr(a-)
140
Associated with ABCG2 ; member of the adenosine triphosphate binding cassette transporters ; involved in multi-drug resistance in tumor cells, named for the antibody maker Rose Jacobs
The Jr (032) system
141
Absence of SMIM1, a single-pass integral membrane protein
The Vel (034) system
142
Based on a CD59-deficient child who formed an alloantibody with CD59 specificity ; complement-regulatory glycoprotein also know as the membrane inhibitor of lysis (MIRL)
CD59 (035) system
143
First described in 1967 in the serum of a black woman named Mrs. Augustine
The Augustine (036) System
144
First described in 1967 in the serum of a black woman named Mrs. Augustine
The Augustine (036) System
145
Located on the prion protein (PrPC) classically associated with Creutzfeldt-Jakob disease (CJD)
Kanno (037)
146
SID (038) antigen found in saliva, urine, MECONIUM
Sd^a
147
The soluble form of Sda is _______ glycoprotein found in urine
Tamm-Horsfall
148
Widely expressed on human tissue, including neutrophils, lymphocytes, and platelets
Choline Transporter-Like Protein 2 (CTL2/SLC44A2) (039)
149
the human neutrophil antigen HNA3 is located on ___
CTL2 -
150
Choline Transporter-Like Protein 2 :
Have been associated with several cases of transfusion-related acute lung injury (TRALI)
Alloantibodies to HNA3a
151
ISBT : 040
PEL
152
ISBT : 041
MAM
153
ISBT : 042
EMM
154
ISBT : 043
ABCC1
155
ISBT : 043
ABCC1
156
ISBT : 044
ER
157
Miscellaneous antigen : receptor of Haemophilus influenza to enter RBCs
AnWj antigen
158
Miscellaneous antigen : HLA antigens that are detectable on mature RBCs : Bennet-Goodspeed
HLA Class I
159
Bga : HLA - __
HLA-B7
160
Bgb : HLA - __
HLA - B17
161
Bgc : HLA - ___
HLA - A28
162
Exhibit reactivity at high dilution of serum, but the strength of agglutination is weak at any dilution ; not clinically significant, but serological reactions make them look they are ; high titer if the antibodies are titered ; the tiers are usually at 1:64 and often will be over 1:1000 ; reactions are very weak and will break apart very readily due to the weak attraction between the antigens and antibodies
High-Titer Low Avidity
