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Study Stuff > OTHER BLOOD GROUP SYSTEMS > Flashcards

OTHER BLOOD GROUP SYSTEMS Flashcards

1
Q

M and N antigens are sensitive to these forms of red cell treatment except:
A. a-chymotrypsin
B. Papain
C. Ficin
D. Trypsin
E. None of the above
~~~

A

A. a-chymotrypsin

M and N are partially reduced by this

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2
Q

The U antigen is sensitive to which form of enzyme treatment?
A. a-chymotrypsin
B. Papain
C. Ficin
D. Trypsin
E. None of the above
~~~

A

E. None of the above

U antigen is resistant to all of thes

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3
Q

Which of the ff red cell treatment is the Lutheran antigens sensitive to?
A. Papain
B. DTT
C. Trypsin
D. Ficin
E. None of the above
~~~

A

C. Trypsin

Sensitive (destrroyed) with trypsin and a-chymotrypsin
Resistant to no effect : papain, ficin, AET, DTT

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4
Q 
Which of the ff Kell phenotypes is most confined in African ancestry?
A. Js (a+b-)
B. Js (a+b+)
C. Kp (a-b+)
D. Kp (a+b+)
A

B. Js (a+b+)

19% of blacks are Js (a+b+), 1% are Js (a+b-)
Js (a+) is confined to people of African ancestry

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5
Q

Kell is RESISTANT to which red cell treatment?
A. EDTA-glycine
B. trypsin
C. AET
D. DTT
~~~

A

B. Trypsin

Kell is sensitive / destroyed by the rest

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6
Q

True / false: suppression of erythropoeisis is associated in anti-K HDFN since Kell glycoproteins appear much earlier in fetal development compared to Rh antigen

A

True

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7
Q

Which of the ff enzymes is the Duffy antigens RESISTANT to?
A. Trypsin
B. Bromelin
C. Ficin
D. a-chymotrypsin
~~~

A

A. Trypsin

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8
Q

True / false: in people of African ethnicity, the phenotype Fy (a-b-) is most common; The Duffy antigens, also found on many cells of the body, is also lacking in individuals with this phenotype, thus, the chances of making Anti-Fy(b), -Fy3, and -Fy5 are very high.

A

False
The Fy(a-b-) phenotype in African ancestry is caused by the silencing of the homozygous FY*02N.01 allele (GATA-1 mutation?) = prevents Fy(b) expression in erythroid (blood cell) tissues. So in this Fy(a-b-) pheno, Fy(b) is lacking only in the red cells, but present in many cells throughout the body so they very rarely make the antibodies.
~~~

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9
Q

Which blood group antigens can be found on the glycoprotein atypical chemokine receptor 1 (ACKR1) of the red cell surface?
A. Kell
B. MNS
C. Kidd
D. Duffy
~~~

A

D. Duffy

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10
Q

Which of the Duffy antigens is absent in not only in Fy(a-b-) phenotype but also in Rh null phenotype?
A. Fy3
B. Fy5
C. Fy6
D. Fyb
~~~

A

B. Fy5

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11
Q

Which of these red cell antigens or proteins is used as a receptor for merozoites like P. vivax (malaria)?
A. Band 3
B. HUT ( urea transporter)l
D. ACKR1 (atypical chemokine receptor)
D. ERMAP (erythroblast membrane associated protein)

A

C. ACKR1
This glycoprotein is present in many organs; but function is unknown
Fy(a-b-) are resistant to malaria; they are NOT necessarily lacking the ACKR1
FY*02N.01 allele mutation may give selective advantage to endemic areas

Band 3 - Diego system
SLC14A1 - kidd system

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12
Q 
Which of these red cell antigens or proteins are the Diego antigens found?
A. Band 3
B. SLC14A1
D. ACKR1
D. ERMAP
A

A. Band 3

Has functions in CO2 transport and attachment of RBC membrane to cytoskeleton

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13
Q 
Which of the ff is associated with he Yt antigens?
A. Fucosylase
B. Urea transporter
C. Acetylcholinesterase
D. Aquaphorins
A

C. Acetylcholinesterase

Yt antigens can be found here

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14
Q

Glycophorin A (GPA), where M and N antigens are found, is associated with the expression of which antigen?
A. Yt(a)
B. Jk(b)
C. Knopps
D. Wr(b)

A

D. Wr(b)

Lack of GPA in RBC membrane recults in failure to express Wr(b)

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15
Q

Which of the ff Diego antibodies reflect dosage?
A. Anti-Wr(b)
B. Anti - Yt(b)
C. Anti - ELO
D. Anti - Di(b)

A

D. Anti - Di(b)

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16
Q

Which of the ff Diego antibodies has shown to have specificity in patients with AIHA?
A. Anti-Wr(b)
B. Anti - Yt(b)
C. Anti - ELO
D. Anti - Di(b)
~~~

A

A. Anti-Wr(b)

17
Q

Which of the ff antibodies is produced by the Dombrock null phenotype?
A. Anti -Hy
B. Anti - Gy(a)
C. Anti - Do(b)
D. Anti - Jo(a)
~~~

A

B. Anti - Gy(a)

18
Q

Which antigens are found on the red cell´s water transporter, aquaporin-1
A. Do
B. Co
C. Yt
D. Sc

A

B. Co

Colton antigens

19
Q

True / false - Fya expression in infants usually reach adult expression at 12 weeks after birth

A

True

20
Q

Which ethnicity is Fya antigen most likely expressed in?
A. Caucasian
B. Blacks
C. Asian
D. Hispanic

A

C. Asian

21
Q

True / false - Anti-Fyb is less immunogenic than anti - Fya

A

True

22
Q

The Jk null phenotype, Jk(a-b-) can potentially produce which antibody?

A

Anti-Jk3

23
Q

Which ethnicity is the phenotype Jk(a-b-) most commonly found?
A. Hispanics
B. Hmong (asians)
C. Polynesians
D. Siberians

A

C. Polynesians

24
Q

Which red cell protein or antigens are the Kidd antigens located at?
A. Band 3
B. SLC14A1
C. ACKR1
D. ERMAP

A

B. SLC14A1

Red cell urea transporter

25
Q

Which method is used to effectively screen donors for the Jk(a-b-) phenotype?
A. Cell lysis with 2M urea
B. Test for agglutination with Rh null red cells
C. RBC inhibition activity with hydatid cyst fluid
D. Donath-Landsteiner test

A

A. Cell lysis with 2M urea
Normal RBCs are lysed by 2M urea (becomes hypertonic then bursts). Jk(a-b-) doesn´t have the SLC14A1 urea transporter so cells do not hemolyze with 2M urea

RBC inhibition activity with hydatid cyst fluid - antisera for P1 inhibition
Donath-Landsteiner test - test for auto anti-P

26
Q

How do you differentiate Anti-LW from anti-D?
A. Test plasma with ficin treated cells; anti-LW will react, anti-D will not
B. Test plasma with trypsin treated cells; anti-LW is non reactive, anti-D will react
C. Test plasma with pronase treated cells; anti-LW will react, anti-D will not
D. Test plasma with DTT treated cells; anti-LW is non reactive, anti-D will react

A

D. Test plasma with DTT treated cells; anti-LW is non reactive, anti-D will react
Anti-LW non reactive and Anti-D is reactive with DTT and pronase treated cells
(Remember anti-D is reactive with DTT)

27
Q 
S and s antigens are sensitive to these forms of red cell treatment except:
A. a-chymotrypsin
B. Bromelin
C. Pronase
D. Trypsin
E. None of the above
A

D. Trypsin

28
Q

Which of the ff high prevalence antigens serves as a receptor for Haemophilus influenza on red cells?
A. Vel
B. ABTI
C. AnWj
D. MAM

A

C. AnWj

29
Q

Anti-Tja can be made by which individuals?
A. P+ individuals
B. P- individuals
C. P null individuals
D. Pk individuals

A

C. P null individuals

Anti- Tja is now renamed Anti-PP1Pk

30
Q

Which of the ff does NOT apply to PP1Pk antibodies?
A. Can cause severe HTR and HDFN
B. Can efficiently bind complement
C. Are made by p individuals
D. All of the above
E. None of the above

A

E. None of the above

Choices A-C applies to PP1Pk

31
Q

Which test can demonstrate the reactivity of autoanti-P?
A. Donath-Landsteiner
B. Neutralization with hydatid cyst fluid
C. Neutralization with saliva
D. Kleihauer-Betke

A

A. Donath-Landsteiner

Demonstrates the biphasic hemolysin characteristic of autoanti-P

32
Q

A rare gene deletion at the GPYA locus produces which phenotype?

A

M-, N-, En(a-)

No GPA is produced = so no M and N antigens produced

33
Q

An immunized individual with the Ko phenotype ( Kell null) can make which antibody?

A

Ku

single specificity; the antibody recognizes the universal (Ku) Kell antigen

34
Q

The M^k M^k phenotype is the null phenotype of which blood group system?

A

MNS system

this phenotype is produced by the rare silent Mk gene
RBCs type as M-N-S-s-U-En(a-), Wr(a-,b-)

35
Q

Individuals who have the McLeod phenotype typically also show which RBC deformity?

A

Acanthocytes

36
Q

Fy^x is the weak form of which Duffy antigen?

A

Fyb

there is no anti-Fy^x

37
Q

Which associated phenoty?pe differentiates Fy5 from Fy3

A

Fy5 is Rh null, Fy(a-,b-)

Fy5 appears to be a result of the interaction between Rh complexes and Duffy glycoproteins

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