COAGULATION / ROTEM / TEG Flashcards
Which disorder is associated with a deficiency in the binding of GPIb and wWF? A. Glanzman thromboastemia B. Bernard Soulier disease C. HIT D. vWD
B. Bernard Soulier disease
Which disorder is associated with a deficiency in the binding of GPIIb/IIIa and fibrinogen? A. Glanzman thromboastemia B. Bernard Soulier disease C. HIT D. vWD
A. Glanzman thromboastemia
Which of the ff will generally show an increase in PTT results? A. Presence of lupus anticoagulant B. Vit K deficiency C. DIC D. multi deficiency due to liver damage E. Hemophilia A or B
A. Presence of lupus anticoagulant
E. Hemophilia A or B
PTT = will asses the intrisic pathway, usually FVIII associated
Which of the ff will generally show an increase in PT results? NEED TO UPDATE THIS SLIDE A. Presence of lupus anticoagulant B. Vit K deficiency C. DIC D. multi deficiency due to liver damage E. Hemophilia A or B
B. Vit K deficiency
II(prothrombin), VII, IX, X, proteins C and S (antifibrinolytic)
Which of the ff will generally show an increase in both PT and PTT results? A. Presence of lupus anticoagulant B. Vit K deficiency C. DIC D. multi deficiency due to liver damage E. Hemophilia A or B
C. DIC
D. multi deficiency due to liver damage
In coagulation studies, which of the ff is used to monitor the activity of direct thrombin inhibitors? A. Thrombin time B. PTT C. Anti-Xa D. D-Dimers
B. PTT
Which of the ff does not result in an elevated thrombin time? A. DIC B. Low or dysfunctional fibrinogen C. Plasminogen inhibitors D. Heparin
C. Plasminogen inhibitors
Plasminogen is the inactive form of plasmin (these lyse clots)
Which of the ff assays is appropriate to use to measure the time for fibrin clot formation in the presence of heparin? A. Reptilase time B. Thrombin time C. Mixing studies D. Rotem Intem parameter values
A. Reptilase time
Insensitive to heparin
Choices B - D are sensitive to heparin
Which of the ff is the most appropriate treatment for a patient with Haemophilia A? A. Novo 7 B. Recombinant factor C. FFP D. Cryo
B. Recombinant factor
Choice A- used only in the presence of high titer inhibitor
Choices C and D - these are no longer used
The ff coagulation results suggests which coagulopathy?
- platelet count, PFA100, RIPA, PT, vWF:Ag = normal
- APTT = increased
- Factor VIII = decreased
A. vWD
B. Haemophilia
C. Lupus
D. Bernard Soulier Disease
B. Haemophilia
Factor VIII deficiency
The ff coagulation results suggests which coagulopathy?
- platelet count, PT, APTT = normal
- PFA100 , RIPA = abnormal
- vWF:Ag = decreased
A. vWD
B. Haemophilia
C. Lupus
D. Bernard Soulier Disease
A. vWD
Which of the ff is NOT affected in the presence of warfarin (levels are normal)? A. FVII B. Protein C C. Prothrombin D. FIX
D. FIX
A mixing study is performed to asses a patient’s coagulation activity. The ff results were obtained at 0 mins and 90 mins:
Correction at 0 mins and 90 mins. What do these results suggest?
A. Suggests a factor deficiency
B. Suggests the presence of heparin or Lupus ag
C. Suggests time / temperature dependent inhibitor
D. No deficiency / normal results
A. Suggests a factor deficiency
A mixing study is performed to asses a patient’s coagulation activity. The ff results were obtained at 0 mins and 90 mins:
Correction at 0 mins but NOT at 90 mins. What do these results suggest?
A. Suggests a factor deficiency
B. Suggests the presence of heparin or Lupus ag
C. Suggests time / temperature dependent inhibitor
D. No deficiency / normal results
C. Suggests time / temperature dependent inhibitor
A mixing study is performed to asses a patient’s coagulation activity. The ff results were obtained at 0 mins and 90 mins:
No correction at 0 mins or at 90 mins. What do these results suggest?
A. Suggests a factor deficiency
B. Suggests the presence of heparin or Lupus ag
C. Suggests time / temperature dependent inhibitor
D. No deficiency / normal results
B. Suggests the presence of heparin or Lupus ag
