BLOOD DONOR SELECTION / BLOOD COLLECTION Flashcards
Which of the following donors would be qualified to donate?
A. A 15 year old female; Hgb = 12.5 g/dL; BP = 100/80 mmHg; Hct = 39% collected by finger prick; heart rate = 60bpm
B. A 34 year old male; Hgb = 12.5 g/dL; BP = 100/80 mmHg; Hct = 39% collected by finger prick; heart rate = 80bpm
C. A 24 year old female; Hgb = 13.5 g/dL; BP = 120/80 mmHg; Hct = 40% collected by earlobe puncture; heart rate = 100 bpm
D. A 65 year old male; Hgb = 14 g/dL; BP = 120/80 mmHg; Hct = 39% collected by finger prick; heart rate = 60bpm
D. A 65 year old male; Hgb = 14 g/dL; BP = 120/80 mmHg; Hct = 39% collected by finger prick; heart rate = 60bpm
BP: systolic = 90 to 180 mmHg
Diastolic = 50 to 100 mmhg
Pulse 50 to 100 bpm
Hgb male = min 13 g/dL Hct 39%
Hgb female = min 12.5 g/dL Hct 38%
Capillary sample from earlobe is not acceptable to use to measure Hct
An apheresis RBC units should contain what level of Hgb as required by AABB standards? A. Greater than or equal to 50% B. Greater than or equal to 55% C. Greater than or equal to 80% D. Greater than or equal to 60%
D. Greater than or equal to 60%
What is the most common reason for blood donor deferrals at most donor centers? A. Travel history B. Low hgb/hct C. Mild Skin disorders D. History of risky sexual activity
B. Low hgb/hct
for mild skin disorders: only unless there are signs of local bacterial infection
True/false - The use of AABB DHQ by blood centers is mandated by the FDA
False
Currently it is not mandated but if any additional information is collected in alternative ways, it must be submitted and approved by the FDA.
True / false - the wording, order and text of the DHQ must not be changed but a blood center facility may make minor changes to the questions only if the change make it more restrictive.
True
True / false - the FDA has implemented regulations that ultimately results in deferral for donors with history of cancer.
False
Currently there are no federal regulations or professional standards regarding criteria to be used for donors with history of cancer
Which of the following donors with a history of cancer would be accepted / not deferred by blood collection facilities?
A. An individual with a history of solid organ malignancy
B. A potential donor with a history of hematologic malignancy (e.g childhood leukemia)
C. A potential donor with a history of superficial squamous cell carcinoma
D. An individual who has recovered from pancreatic cancer
C. A potential donor with a history of superficial squamous cell carcinoma
A - deferred for 1-5 years
B - permanently deferred, but some blood centers accept
D - this is an example of solid organ cancer; deferred
Which of the following donors with factor deficiency would be allowed to donate? A. Donor with FXII deficiency B. Donor with FVIII deficiency C. Donor with FV deficiency D. Donor with FX deficiency
A. Donor with FXII deficiency - not associated with bleeding and thrombosis
Which of the following individuals would be the most appropriate candidate for autologous blood donation?
A. A 67 year old man with Hgb = 8.0 g/dL who had myocardial infarction 2 months before surgery; has history of Anti-Jkb
B. A 30 year old female with ongoing symptoms of pulmonary disease; Hgb = 13.5 g/dL
C. A female with no history of heart disorder, has had 3 pregnancies; Hgb = 12 g/dL; no known antibodies
D. A male preop patient with a history of multiple alloantibodies against rare blood antigens; Hgb = 12.5 g/dL
D. A male preop patient with a history of multiple alloantibodies against rare blood antigens; Hgb = 12.5 g/dL
Ideal candidate:
- alloimmunized pt for whom compatible units arehard to collect
- who will undergo elective surgery and will likely require tx
- will have adequate time to replace Hgb lost from phlebotomy
Minimum hemoglobin concentration of
11 g/dL or hematocrit of 33%.
True / false - platelets are taken from whole blood after it has cooled down to 18C after donation.
False
Must be collected w/in 8 hrs, WB shoud not be cooled down below 20C
What are the three agents most commonly used to increase granulocyte yield in donors?
Hydroxyethyl starch (HES)
Corticosteroids
Growth factors
What is the optimal therapeutic dose of a granulocyte component (for adults) as required by AABB Standards? A. 1 x 10^10 B. 2.5 x 10^10 C. 10-15 ml/kg D. 15 - 25 ml/kg
A. 1 x 10^10
10 - 15 ml/ kg is the dosage for infants
Which of the following statement applies to granulocyte components?
A. The component must be from a donor of the same blood type as the recipient (ABO matching)
B. Compatibility crossmatching is not necessary for a granulocyte component cpntaining a maximum of 2ml RBCs as long as the component is ABO compatible to the recipient
C. Granulocyte components must be irradiated before transfusion
D. A microaggregate filter should be used during transfusion of granulocyte components
C. Granulocyte components must be irradiated before transfusion
A - component must be ABO compatible with recipient’s plasma
B - XM for Rh and HLA compatibility is needed if >2ml of RBCs is present
D - microaggregate and LR filters will remove the granulocytes
As per AABB requirement, which of the following component is the most suitable unit to be transfused to reduce the risk of transfusion related acute lung injury (TRALI)?
A. Platelet collected from a female with a history of two pregnancies, HLA status unknown
B. Plasma collected from a female with no history of pregnancy, has been tested negative for HLA antibodies
C. Platelet collected from a male, HLA status unknown
D. Plasma collected from a pregnant female, has been tested negative for HLA antibodies
C. Platelet collected from a male, HLA status unknown
Components must be from males
NEVER from a pregnant female
Can be from parous female donors who test negative for HLA antibodies
\_\_\_\_\_\_\_\_\_ is a by product of cryoprecipitate preparation A. Recovered plasma B. Liquid plasma C. Plasma cryoprecipitate reduced D. Cryoprecipitate
C. Plasma cryoprecipitate reduced`
Which of the following does not apply to Plasma cryoprecipitate reduced?
A. Fibirinogen levels remain at ~200mg/dL
B. vWF and vWF activity are decreased
C. Level of Factor V are reduced
D. Fibrinogen levels are decreased
C. Level of Factor V are reduced
This component has:
- normal level of factor V (85%), Factor I, Factor VII, Factor X
- normal levels of antiplasmin, antithrombin, Protein C, Protein S
- Fibrinogen levels are reduced but remain at ~200mg
- decreased FVIII, vWF antigen and activity, and FXIII
Which of the following statements regarding FVIII and fibrinogen content is cryoprecipitate is true?
A. Must have 170 units/bag of FVIII, 60 units/bag of fibrinogen
B. Must contain at least 100 IU of FVIII, 150mg of fibrinogen
C. Must contain at least 80 IU of FVIII, and at least 388mg of fibrinogen
D. Must have at least 80 IU of FVIII, 150mg of fibrinogen
D. Must have at least 80 IU of FVIII, 150mg of fibrinogen
Other content:
- 170 units/bag of vWF ristocetin factor
- 60 units/ bag FXIII
- 388 mg/unit is the current median level of fibrinogen
At what pH must platelets be maintained at to ensure adequate in-vivo recovery?
~ 6.5 pH, must not be below 6.2 pH
