HSCT / STEM CELL Flashcards
________ are primitive pluripotent cells that are capable of self renewal and are utilized to treat a diverse array of hematologic and non-hematologic diseases and conditions.
Hematopoeitic progenitor cells
True / false - CD34 are uniquely found in HPCs therefore, they are used for their identification and quantification.
False
CD34 are not specific to HPCs but 2nd part is true
Which of the ff is the best choice as an allogeneic transplant donor? A. HLA unmatched related donor B. HLA matched related donor C. HLA unmatched unrelated donor D. HLA matched unrelated donor
B. HLA matched related donor
Choice D may work as well in pts with AML or myelodysplastic syndrome
Aside from HLA compatibility, which of the ff donor factors / characteristics has been associated with transplant survival? A. ABO compatibility B. CMV status C. Age of donor D. Gender
C. Age of donor
Younger donor associated with higher survival????
Which of the ff sources of HPCs have a greater transplant survival in patients with late stage hematologic malignancies who received transplant from a matched related donor? A. Mobilized peripheral blood B. Marrow C. UCB D. Autologous marrow transplant
A. Mobilized peripheral blood
What is the minimum total nucleated cell (TNC) count for HPCs collected from the marrow? A. 5 x 10^6 B. 2 x 10^6 C. 2 x 10^8 D. 5 x 10^8
C. 2 x 10^8
What is the minimum desirable number of cells needed for HPCs collected from peripheral blood? A. 5 x 10^6 B. 2 x 10^6 C. 2 x 10^8 D. 5 x 10^8
A. 5 x 10^6
This is the desirable amount, choice B is minimum
_____ is the rapid generation of anti-A and or anti-B by donor lymphocytes against recipient red cells.
Passenger lymphocyte syndrome
True / false - in non ABO red cells incompatible transplantation, the presence of RHD antigen incompatibility is not likely to result in serious clinical consequence.
True
Some patients undergoing hematopoietic stem cell transplantation have antibodies against HLA/ HPA antigens, which may reduce platelet transfusion efficacy. Which of the ff may help prevent potential problems in recipient engraftment in the presence of HLA / HPA alloantibodies?
A. Therapeutic red cell exchange
B. Infusion of HLA matched platelets
C. Infusion of crossmatch compatible ABO identical platelets
D. Therapeutic plasma exchange
D. Therapeutic plasma exchange
Can be used to (temporarily?) desensitize potential transplant recipients to HLA antigens
Which hematopoietic stem cell transplant (HSCT) compatibility category does the ff fall under:
Group A recipient; Group B donor
A. Bidirectional
B. Major
C. Minor
D. Identical
A. Bidirectional
Which hematopoietic stem cell transplant (HSCT) compatibility category does the ff fall under:
Group A recipient; Group AB donor
A. Bidirectional
B. Major
C. Minor
D. Identical
B. Major
Major - allo ab in recipient plasma
Minor - allo ab in donor graft plasma
Which hematopoietic stem cell transplant (HSCT) compatibility category does the ff fall under:
Group AB recipient; Group B donor
A. Bidirectional
B. Major
C. Minor
D. Identical
C. Minor
Major - allo ab in recipient plasma
Minor - allo ab in donor graft plasma
Which hematopoietic stem cell transplant (HSCT) compatibility category does the ff fall under:
Group O recipient; Group AB donor
A. Bidirectional
B. Major
C. Minor
D. Identical
B. Major
Major - allo ab in recipient plasma
Minor - allo ab in donor graft plasma
Which hematopoietic stem cell transplant (HSCT) compatibility category does the ff fall under:
Group B recipient; Group O donor
A. Bidirectional
B. Major
C. Minor
D. Identical
C. Minor
Major - allo ab in recipient plasma
Minor - allo ab in donor graft plasma
