Other antiparasitics Flashcards
mechanism of pentamidine
inhibits glycolysis and nucleic acid metabolism
indications of pentamidine
pneumocytstosis
trypanosoma
kala azar leishmania
side effects of pentamidine
respiratory distress hypotension hypoglycemia anemia hepatitis pancreatitis
mechanism of sodium stibogluconate
inhibits glycolysis and nucleic acid metabolism
indications for sodium stibogluconate
leishmaniasis
sodium stibogluconate side effects
QT prolongation
mechanism of eflornithine
suicide substrate of ornithine decarboxylase
indication for eflornithine
african trypanosomiasis
eflornithine side effects
hematotoxicity
seizures
nifurtimox mechanism
inhibits trypanothione reductase
indication for nifurtimox
chagas disease
nifurtimox side effects
GI Irritation
CNS effects
albendazole mechanism
inhibits microtubule synthesis and blocks glucose uptake
diethylcarbamazine citrate mechanism
immobilizes microfilia and alters surface structure
albendazole side effects
altered blood count and LFTS
diethylcarbamazine citrate
HA malaise anorexia weakness mazzotti reaction
what is the mazzotti reaction
fever
chills
respiratory distress
hypotension
ivermectin mechanism
paralyzes nematodes and arthropods by intensifying GABA
side effects of ivermectin
fever HA dizziness somnolence rash pruritis arthralgia myalgia hypotension
mechanism of praziquantel
causes paralysis of worms by increasing permeability of calcium
side effects of praziquantel
fever
rash
arthralgias
neuro abnormalities
