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Antibiotics > Other antiparasitics > Flashcards

Other antiparasitics Flashcards

1
Q

mechanism of pentamidine

A

inhibits glycolysis and nucleic acid metabolism

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2
Q

indications of pentamidine

A

pneumocytstosis
trypanosoma
kala azar leishmania

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3
Q

side effects of pentamidine

A 
respiratory distress
hypotension
hypoglycemia
anemia
hepatitis
pancreatitis
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4
Q

mechanism of sodium stibogluconate

A

inhibits glycolysis and nucleic acid metabolism

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5
Q

indications for sodium stibogluconate

A

leishmaniasis

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6
Q

sodium stibogluconate side effects

A

QT prolongation

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7
Q

mechanism of eflornithine

A

suicide substrate of ornithine decarboxylase

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8
Q

indication for eflornithine

A

african trypanosomiasis

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9
Q

eflornithine side effects

A

hematotoxicity

seizures

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10
Q

nifurtimox mechanism

A

inhibits trypanothione reductase

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11
Q

indication for nifurtimox

A

chagas disease

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12
Q

nifurtimox side effects

A

GI Irritation

CNS effects

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13
Q

albendazole mechanism

A

inhibits microtubule synthesis and blocks glucose uptake

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14
Q

diethylcarbamazine citrate mechanism

A

immobilizes microfilia and alters surface structure

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15
Q

albendazole side effects

A

altered blood count and LFTS

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16
Q

diethylcarbamazine citrate

A 
HA
malaise
anorexia
weakness
mazzotti reaction
17
Q

what is the mazzotti reaction

A

fever
chills
respiratory distress
hypotension

18
Q

ivermectin mechanism

A

paralyzes nematodes and arthropods by intensifying GABA

19
Q

side effects of ivermectin

A 
fever
HA
dizziness
somnolence
rash
pruritis
arthralgia
myalgia
hypotension
20
Q

mechanism of praziquantel

A

causes paralysis of worms by increasing permeability of calcium

21
Q

side effects of praziquantel

A

fever
rash
arthralgias
neuro abnormalities

Antibiotics (7 decks)

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