Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Antibiotics > Antibacterial Mechanisms > Flashcards

Antibacterial Mechanisms Flashcards

1
Q

Mechanism of penicillins

A

structural analog of D-Ala-D-Ala that binds transpeptidases to block peptidoglycan cross-linking in the cell wall

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Extended spectrum penicillins

A

penicillinase sensitive penicillins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

penicillinase sensitive penicillins

A

Amoxicillin

Ampicillin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Narrow Spectrum penicillins

A

penicillinase resistant penicillins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

penicillinase resistant penicillins

A

Dicloxacillin
Nafcillin
Oxacillin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Antipseudomonals

A

ticarcillin

piperacillin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

beta lactam inhibitors

A

clavulanic acid
sulbactam
tazobactam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Mechanism of Monobactams

A

prevents peptidoglycan cross linking by binding to PBP3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Mechanism of Vancomycin

A

inhibits cell wall peptidoglycan formation by binding to D-Ala-D-Ala portion of cell wall precursors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Mechanism of aminoglycosides

A

irreversible inhibition of initiation complex by binding 30S ribosomal subunit

causes misreading of mRNA and blocks translocation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Mechanism of tetracyclines

A

binds to 30S ribosomal subunit to prevent attachment of aminoacyl-tRNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Mechanism of Chloramphenicol

A

inhbits peptidyl transferase at 50S subunit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Mechanism of Clindamycin

A

blocks translocation by binding to 50S subunit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Mechanism of Linezolid

A

inhibits protein synthesis by binding to 50S subunit and preventing the formation of the initiation complex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Mechanism of Macrolides

A

inhibits protein synthesis by binding to the 23S rRNA of the 50 ribosomal subunit and blocking translocation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Mechanism of polymixins

A

bind to phospholipids on cell membranes to disrupt membrane integrity and cause leakage of cellular components

17
Q

Mechanism of Sulfonamides

A

inhibits dihydropterate synthase to inhibit folate synthesis

18
Q

Mechanism of Dapsone

A

inhibits dihydropterate synthase to inhibit folate synthesis

19
Q

Mechanism of trimethoprim

A

inhibits bacterial dihydrofolate reductase

20
Q

Mechanism of Fluoroquinolones

A

inhibits prokaryotic DNA Gyrase

21
Q

Mechanism of Daptomycin

A

disrupts cell membranes by creating transmembrane channels (pores)

22
Q

Mechanism of Metronidazole

A

forms toxic free radicals in the cell that damages DNA

23
Q

Mechanism of Rifampin

A

inhibits DNA dependent RNA polymerase

24
Q

Mechanism of Isoniazid

A

decreases synthesis of mycolic acids

25
Q

Mechanism of Ethambutol

A

blocks arabinosyltransferase, which decreases carbohydrate polymerization of mycobacterium cell wall

26
Q

Mechanism of Streptomycin

A

interferes with 30S ribosomal subunit

Antibiotics (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions