Mechanisms of other Anti-Microbials Flashcards

1
Q

Mechanism of Amantidine

A

blocks M2 proton ion channels in influenza A

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2
Q

Mechanism of Ribivirin

A

inhibits IMP dehydrogenase, causing a deficiency in GTP

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3
Q

Mechanism of Acyclovir

A

Guanosine analog that inhibits viral DNA polymerase

causes chain termination

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4
Q

Mechanism of Famciclovir/ Valacyclovir

A

Guanosine analog that inhibits viral DNA polymerase

causes chain termination

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5
Q

Mechanism of Ganiciclovir

A

inhibits viral DNA polymerase, but does not cause chain termination

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6
Q

Mechanism of Foscarnet

A

inhibits viral DNA/RNA polymerase and HIV reverse transcriptase by binding to pyrophosphate

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7
Q

Mechanism of Zanamavir/ Oseltamavir

A

inhibit neuraminidase in Influenza A

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8
Q

Mechanism of Metronidazole

A

creates free radicals by inhibiting pyruvate ferredoxin oxidoreductase

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9
Q

Mechanism of Quinine

A

prevents DNA strand separation, blocking replication and RNA transcription

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10
Q

Mechanism of Chloroquine

A

blocks conversion of heme into hemozoin, making toxic for parasites

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11
Q

Mechanism of Primaquine

A

cellular oxidant

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12
Q

Mechanism of Albendazole

A

inhibits microtubule synthesis and blocks glucose uptake

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13
Q

Mechanism of Praziquantel

A

increases permeability of calcium in the parasite, causing paralysis

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14
Q

Mechanism of Amphotericin B

A

binds to ergosterol and forms pores in membrane

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15
Q

Mechanism of Azoles

A

inhibits fungal ergosterol synthesis by inhibiting the CYP450 enzyme that converts lanosterol to ergosterol

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16
Q

Mechanism of Griseofulvin

A

interferes with microtubule function, preventing mitosis

17
Q

Mechanism of Terbinafine/ Naftifine

A

inhibits squalene epoxidase

18
Q

Mechanism of Caspofungin

A

inhibits cell wall synthesis by inhibiting Beta-glucan synthesis

19
Q

Mechanism of Flucytosine

A

converts to 5-FU via cytosine deaminase, then inhibiting DNA and RNA synthesis