Mechanisms of other Anti-Microbials Flashcards
Mechanism of Amantidine
blocks M2 proton ion channels in influenza A
Mechanism of Ribivirin
inhibits IMP dehydrogenase, causing a deficiency in GTP
Mechanism of Acyclovir
Guanosine analog that inhibits viral DNA polymerase
causes chain termination
Mechanism of Famciclovir/ Valacyclovir
Guanosine analog that inhibits viral DNA polymerase
causes chain termination
Mechanism of Ganiciclovir
inhibits viral DNA polymerase, but does not cause chain termination
Mechanism of Foscarnet
inhibits viral DNA/RNA polymerase and HIV reverse transcriptase by binding to pyrophosphate
Mechanism of Zanamavir/ Oseltamavir
inhibit neuraminidase in Influenza A
Mechanism of Metronidazole
creates free radicals by inhibiting pyruvate ferredoxin oxidoreductase
Mechanism of Quinine
prevents DNA strand separation, blocking replication and RNA transcription
Mechanism of Chloroquine
blocks conversion of heme into hemozoin, making toxic for parasites
Mechanism of Primaquine
cellular oxidant
Mechanism of Albendazole
inhibits microtubule synthesis and blocks glucose uptake
Mechanism of Praziquantel
increases permeability of calcium in the parasite, causing paralysis
Mechanism of Amphotericin B
binds to ergosterol and forms pores in membrane
Mechanism of Azoles
inhibits fungal ergosterol synthesis by inhibiting the CYP450 enzyme that converts lanosterol to ergosterol