Anti malaria Flashcards
mechanism of chloroquine
inhibits parasite ability to digest hemoglobin
chloroquine side effects
pruritis blury vision retinopathy N?V irreversible ototoxicity myopathy peripheral neuropathy Hemolytic anemia in G6PD
chloroquine contraindications
psoriasis
porphyria
mechanism of quinine and quinidine
complexes with DNA to prevent strand separation. blockade of DNA replication and transcription to RNA
what else can quinine/quinidine be used for
Babesiosis
Side effects of quinidine/quinine
tinnitus headache nausea dizziness fluhing visual disturbance hypersensitivity blackwater fever hypersensitivity hemolysis in G6PD
contraindications of quinine/ quinidine
vision, auditory or cardiac dysfunction
when would you use mefloquine over chloroquine
chloroquine-resistant malaria
mefloquine side effects
psych problems
cardiac problems
seizures
indication for primaquine
eradication of liver forms of vivax and ovale
primaquine mechanism
acts as an oxidant to cause parasitic stress
primaquine side effects
hemolysis and methemaglobinemia in G6PD
contraindications of primaquine
granulocytopenia
methemaglobinemia
pregnancy
mechanism of atovaquone
disrupts malarial ETC
indication for atovaquone
prophylaxis and treatment of p.falciparum and pneumocystis jirovecii
side effects of atovaquone
gi distress
elevated LFTs
flu like symptoms
side effect of doxycycline
phototoxicity
mechanism of metronidazole
inhibits pyruvate ferredoxin oxioreductase to form cytotoxic products in the parasite
side effects of metronidazole
metallic taste disulfiram like reaction HA paresthesias dark urine
contraindications of metronidazole
neurologic disorders
side effects of iodoquinol
iodine toxicity
thyroid dysfunction
peripheral neuropathy
mechanism of paromomycin
inhibits protein synthesis
paramomycin side effects
dizziness
rash
arthralgias
mechanism of artemether
inhibits parasite calcium ATPase
artemether indications
complicated p. falciparum
artemether side effects
N/V/D dizziness neutropenia elevated LFTs allergic reactions
