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Antibiotics > Anti malaria > Flashcards

Anti malaria Flashcards

1
Q

mechanism of chloroquine

A

inhibits parasite ability to digest hemoglobin

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2
Q

chloroquine side effects

A 
pruritis
blury vision
retinopathy
N?V
irreversible ototoxicity
myopathy
peripheral neuropathy
Hemolytic anemia in G6PD
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3
Q

chloroquine contraindications

A

psoriasis

porphyria

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4
Q

mechanism of quinine and quinidine

A

complexes with DNA to prevent strand separation. blockade of DNA replication and transcription to RNA

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5
Q

what else can quinine/quinidine be used for

A

Babesiosis

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6
Q

Side effects of quinidine/quinine

A 
tinnitus
headache
nausea
dizziness
fluhing
visual disturbance
hypersensitivity
blackwater fever
hypersensitivity
hemolysis in G6PD
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7
Q

contraindications of quinine/ quinidine

A

vision, auditory or cardiac dysfunction

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8
Q

when would you use mefloquine over chloroquine

A

chloroquine-resistant malaria

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9
Q

mefloquine side effects

A

psych problems
cardiac problems
seizures

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10
Q

indication for primaquine

A

eradication of liver forms of vivax and ovale

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11
Q

primaquine mechanism

A

acts as an oxidant to cause parasitic stress

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12
Q

primaquine side effects

A

hemolysis and methemaglobinemia in G6PD

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13
Q

contraindications of primaquine

A

granulocytopenia
methemaglobinemia
pregnancy

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14
Q

mechanism of atovaquone

A

disrupts malarial ETC

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15
Q

indication for atovaquone

A

prophylaxis and treatment of p.falciparum and pneumocystis jirovecii

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16
Q

side effects of atovaquone

A

gi distress
elevated LFTs
flu like symptoms

17
Q

side effect of doxycycline

A

phototoxicity

18
Q

mechanism of metronidazole

A

inhibits pyruvate ferredoxin oxioreductase to form cytotoxic products in the parasite

19
Q

side effects of metronidazole

A 
metallic taste
disulfiram like reaction
HA
paresthesias
dark urine
20
Q

contraindications of metronidazole

A

neurologic disorders

21
Q

side effects of iodoquinol

A

iodine toxicity
thyroid dysfunction
peripheral neuropathy

22
Q

mechanism of paromomycin

A

inhibits protein synthesis

23
Q

paramomycin side effects

A

dizziness
rash
arthralgias

24
Q

mechanism of artemether

A

inhibits parasite calcium ATPase

25
Q

artemether indications

A

complicated p. falciparum

26
Q

artemether side effects

A 
N/V/D
dizziness
neutropenia
elevated LFTs
allergic reactions

Antibiotics (7 decks)

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