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Antibiotics > Antibiotics > Flashcards

Antibiotics Flashcards

1
Q

Penicillin side effects

A

hypersensitivity reactions
Direct coombs test positive
hemolytic anemia
drug induced interstitial nephritis

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2
Q

Extended spectrum penicillin side effects

A

hypersensitivity reactions
rash
pseudomembranous colitis

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3
Q

Narrow Spectrum penicillin side effects

A

hypersensitivity reaction

interstitial nephritis

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4
Q

antipseudomonals

A

hypersensitivity reactions

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5
Q

cephalosporin side effects

A

cross hypersensitivity reactions with penicillins
autoimmune hemolytic anemia
disulfiram like reaction
vitamin K deficiency/ platelet dysfunction/ bleeding

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6
Q

carbapenem side effects

A 
cross hypersensitivity  reactions with penicillins 
Gi distress
Rash
seizures
anemia
leukopenia
thrombocytopenia
altered bleeding time
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7
Q

aztreonam side effects

A

hypersensitivity reactions
GI distress
thrombophebitis

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8
Q

Vancomycin side effects

A 
red man syndrome
ototoxicity
nephrotoxicity
thrombophlebitis
DRESS syndrome (eosinophilia)
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9
Q

Bacitracin side effects

A

nephrotoxcity

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10
Q

cephalosporin complications

A

potentiates effects of anticoagulant and antiplatelet drugs

increased nephrotoxicity of aminoglycosides

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11
Q

aminoglycoside mechanism

A

bind to 30S to inhibit formation of initiation complex, causing misreading of mRNA and blocking translocation

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12
Q

aminoglycoside side effects

A

nephrotoxicity
ototoxicity
teratogen
weakness

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13
Q

how are most aminoglycosides used

A

topically

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14
Q

Tetracycline mechanism

A

binds to 30S subunit to prevent attachment of amino-acyl tRNA

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15
Q

tetracycline side effects

A 
photosensitivity
enamel hypoplasia
nephrotoxicity
hepatotoxicity
teeth discoloration in children
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16
Q

macrolide mechanism

A

binds to 23s subunit of 50S to block translocation

17
Q

macrolide side effects

A 
stomatitis
heartburn
nausea
diarrhea
abd pain
anorexia
18
Q

what causes erythromycin side effects

A

binding of motilin causes uncoordinated peristalsis

19
Q

erythromycin side effects

A

ototoxicity
thrombophlebitis
carbamazepine toxicity

20
Q

telithromycin side effects

A 
liver toxicity
prolonged QT
respiratory failure in myasthenia gravis
impaired visual accommodation
temporary LOC
21
Q

streptogrammin side effects

A 
venous inflammation
arthralgias/ myalgias
elevaated LFTs
nausea
diarrhea

Antibiotics (7 decks)

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