Antibiotics Flashcards
Penicillin side effects
hypersensitivity reactions
Direct coombs test positive
hemolytic anemia
drug induced interstitial nephritis
Extended spectrum penicillin side effects
hypersensitivity reactions
rash
pseudomembranous colitis
Narrow Spectrum penicillin side effects
hypersensitivity reaction
interstitial nephritis
antipseudomonals
hypersensitivity reactions
cephalosporin side effects
cross hypersensitivity reactions with penicillins
autoimmune hemolytic anemia
disulfiram like reaction
vitamin K deficiency/ platelet dysfunction/ bleeding
carbapenem side effects
cross hypersensitivity reactions with penicillins Gi distress Rash seizures anemia leukopenia thrombocytopenia altered bleeding time
aztreonam side effects
hypersensitivity reactions
GI distress
thrombophebitis
Vancomycin side effects
red man syndrome ototoxicity nephrotoxicity thrombophlebitis DRESS syndrome (eosinophilia)
Bacitracin side effects
nephrotoxcity
cephalosporin complications
potentiates effects of anticoagulant and antiplatelet drugs
increased nephrotoxicity of aminoglycosides
aminoglycoside mechanism
bind to 30S to inhibit formation of initiation complex, causing misreading of mRNA and blocking translocation
aminoglycoside side effects
nephrotoxicity
ototoxicity
teratogen
weakness
how are most aminoglycosides used
topically
Tetracycline mechanism
binds to 30S subunit to prevent attachment of amino-acyl tRNA
tetracycline side effects
photosensitivity enamel hypoplasia nephrotoxicity hepatotoxicity teeth discoloration in children
macrolide mechanism
binds to 23s subunit of 50S to block translocation
macrolide side effects
stomatitis heartburn nausea diarrhea abd pain anorexia
what causes erythromycin side effects
binding of motilin causes uncoordinated peristalsis
erythromycin side effects
ototoxicity
thrombophlebitis
carbamazepine toxicity
telithromycin side effects
liver toxicity prolonged QT respiratory failure in myasthenia gravis impaired visual accommodation temporary LOC
streptogrammin side effects
venous inflammation arthralgias/ myalgias elevaated LFTs nausea diarrhea
