Osteoporosis Flashcards
1
Q
Osteoporosis Definition
A
-Progressive skeletal disease with reduced bone mass and micro-architectural deterioration of bone-tissue
2
Q
Osteoporosis Bone Density Value
A
- ≥1 is normal
- Between -1 and -2.5 is osteopenia
- ≤2.5 is osteoporosis
- DEXA scan most commonly used
3
Q
Osteoporosis Epidemiology
A
- Age related
- More common in women
4
Q
Osteoporosis Secondary Causes
A
RA, primary hyperparathyroidism, CKD, IBD, T1DM
5
Q
Osteoporosis Presentation
A
- Process is asymptomatic
- Usually presents after bone fracture
- Most common in spine, hip and wrist
6
Q
Osteoporosis Investigations
A
- DEXA is gold standard
- Screen for endocrine/autoimmune causes
7
Q
Osteoporosis Fracture Risk Assessment Score, Interpretation
A
FRAX
-Probability of major osteoporotic fracture in next 10 years
8
Q
Osteoporosis Management
A
- Bisphosphonate (try alendronate then either risedronate or etidronate)
- Denosumab second line in women, third line in men (reduces osteoclast activity)
- Teriparatide third line in women, second line in men (PTH receptor agonist)
- Raloxifene 4th line in women
