osteoporosis

Question 0

Stimulates osteoclast formation,differentiation and activation

Answer 0

Binding of RANKL to RANK

Question 1

Definition of OSteoporosis

Answer 1

Skeletal Disorder characterized by compromised predisposing a person to an increased risk of Fracture

Question 2

causes of Vit D deficiency

Answer 2

1 reduced skin synthesis
2 DEc. bioavailability
3 inc, catabolism
4 Breast feeding
5 25-oh vit and 1,25-oh vit d (Liver and kidney problems respectively

Question 3

Age and weight are determinants in classifying patients as having high risk, medium risk or low risk for fracture

Answer 3

Osteoporosis Screening Toll For Asians (OSTA)

Question 4

modifiable Clinical Risk FActors for low LOw BMD

Answer 4

1 Low calcium intake and Vit D, smoking, sedentary, Low Body Weight

Question 5

Risk factors for BMD

Answer 5

1 Non-modifiable and modifiable
2 Genetics (ehler danlos, marfan)
3 Hypogonadal States (Premature ovarian failire
4 Endocrine Disorders
5 Rheumatologic disorders (SLE,RA,SA)
6 Medications (heparin, cancer chemo, GRHA,Anticovulsants, tacrolimus,lithium,glucocoticoids)

Question 6

What is WHO FRAX?

Answer 6

Fracture Risk Assessment Tool
Calculates the 10 year probability of fracture with BMD
Takes into account AGE, Weight,presence of fracture, glucocorticoid use

Question 7

Diagnosis in Post Menopausal women (FRAX)

Answer 7

Tscore= 1.o greater (normal)
OSteopenia = -1 to -2.5
Osteoporosis = -2.5 or less

Question 8

GOLD standard for bone density analysis what does it detect

Answer 8

DXA MAchine, bone and soft tissue

Question 9

osteoporotic based on the densitometric definition

Answer 9

Bone density more than 2.5 SD below the mean for young adult women (osteopenia is 1.0 and 2,5 SD BELOW the mean for young adult woemn.

Question 10

Osteoporosis in Men using DXA

Answer 10

T-score <-2.0 with risk and known secondary factors

Question 11

The WHO criteria cannot be applied to

Answer 11

1 PEripheral DXA other tahn the forearm
Quantitative CT
Quantitative US

Question 12

when to initiate TX accdg to NOF

Answer 12

postmenopausal women and 50 year old male with low bone mass at the FEMORAL NECK, SPINE, 10 year hip fracture probability >/= 3 %

Question 13

adequate intak of CAlcium

Answer 13

1000 mg for men 50 0 70
1200 mg per day for women 51 and older and men 71 and older
Vit D: 800 - 1000 IU/day

Question 14

Causes of Vitamin D deficiency

Answer 14

REduced skin synthesis, Dec Bioavailability, incr catabolism, Breastfeeding, dec synthesis of 25-OH Vit D and 1,25-OH vit D

Question 15

Serum 25(OH) F level that is recommended

Answer 15

75 nmol/L

Question 16

stable analogues of pyropohoshate chacaterised by a PCP bond

Answer 16

Bisphosphonates - disables bone resorption, and increases osteoclast apoptosis

Question 17

Endogenous polypeptide hormone that inhibits osteoclastic bone resoption

Answer 17

calcitonin

Question 18

Raloxifene?

Answer 18

Estrogen agonist, Agonistic activity on estrogen receptors leads to a reduction of Bone resorption

Question 19

Teriparatide

Answer 19

PTH hormone 1-34 - icnreases activity of osteoblasts

Question 20

Denosumab

Answer 20

RANKL inhibitor

Question 21

STrontium RAnelate - MOA and supresses what factor

Answer 21

osteoclasts and osteoblasts precursors treated with ____ promoted osteoblast activity abd supressed osteoclastogensis, based on supression of nuclear factor - Kappa B signal transduction

Question 22

Side effect of RAloxifene

Answer 22

DVT

Question 23

SE of Nausea, leg crams , dizziness

Answer 23

Teriparatide (PTH)