osteoporosis

Question 1

pharmacological tx for osteoporosis

Answer 1

bisphosphonate
denosumab
raloxifene
teriparatide
hormone replacement therapy

Question 2

Essential factors for bone densit

Answer 2

Vit D
Ca
Sex hormone
PTH hormone
Bone homeostasis

Question 3

Body parts which are more susceptible to fracture

Answer 3

wrist
Hip
Lower back

Question 4

Bisphophonate (oral) has to be used for how long

Answer 4

5 yrs

Question 5

Bisphosphonate MOA

Answer 5

inhibit the activity of osteoclast

Question 6

should bisphosphonate be taken w food ? Y/N

Answer 6

N—poor absorptio

Question 7

should ca2+ supplement be taken w bisphosphonate Y/N

Answer 7

N—inhibit the absorption of bisphosphonate

Question 8

denosumab MOA

Answer 8

inhibit RANKL —-inhibit the activsation of osteoclast

Question 9

there is no need to correct vit D deficiency before starting the denosumab Y/N

Answer 9

N (denosumab wll cause hypocalcaemia

Question 10

raloxifene MOA

Answer 10

estrogen agonist in bone

Question 11

raloxifene is more appropriate for preventing spinal fracture Y/N

Answer 11

Y

Question 12

teriparatide MOA

Answer 12

promote the bone formation

Question 13

only specialist can initiate the teriparatide tx Y/N

Answer 13

Y

Question 14

HRT is not recommended for patient age > 60 Y/N

Answer 14

Y

Question 15

HRT is not recommended for the solely purpose of preventing osteoporosis Y/N

Answer 15

Y

Question 16

medications which may increase the risk of osteoporosis

Answer 16

Aromatase inhibitor
PPI
SSRI
Glucocorticoid
GnRH angonist
Antiepileptic
pioglitazone