diabete medication

Question 1

SGLT2 inhibitor MOA

Answer 1

Inhibit sodium-glucose cotransporter—inhibit the reabsorption of glucose (proximal tubule)

Question 2

SGLIT2 inhibitor end with

Answer 2

gliflozin

Question 3

Advantages of SGLT2 inhibitor

Answer 3

low risk of hypoglycaemia
weight loss
BP reduction
cardiovasular and renal benefit

Question 4

Drawbacks of SGLT2 inhibitor

Answer 4

euglycaemic DKA (esp when fasting, hence avoid before surgery)
need to have a normal kidney function ir order for it to work (CrCl> 45)
dehydration
genital infection

Question 5

Alphaglucosidase MOA

Answer 5

inhibit the alpha glucosidase in the border of the small intestine
delay the CHO absorption

Question 6

Alphaglucosidase example

Question 7

Alphaglucosidase advantages

Answer 7

it has a low risk of hypoglycaemia (however, be aware that it is usually a add-on therapy, hence, may still at risk of hypoglycaemia/ when this happen—use glucose to correc it)

Question 8

Alphaglucosidase drawbacks

Answer 8

GI side effect
Have to chew this tablet w the meal

Question 9

Thiazolieinediones MOA

Answer 9

PPAR–gamma agonist
increase sensitivity of the insulin

Question 10

Thiazolidinediones end with

Answer 10

glitazone

Question 11

Advantages of thiazolidinediones

Question 12

Drawbacks of thiazolidinediones

Question 13

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