menopause

Question 1

MOA of tibolene (acts like a estrogen at…..)

Answer 1

acts like estrogen at:
a) brain (preventing hot flush)
b) bone (osteoporosis)
c) vaginal tissue (dryness)

Question 2

tiobolone is suitable for women with no natural period > 1 y
Y/N

Answer 2

Y

Question 3

examples of estrogen selective modulator

Answer 3

raloxifene
bazedoxifene

Question 4

raloxifene is used to treat

Answer 4

osteoporosis

Question 5

raloxifene has estrogenic effect on some organs and anti-estrogenic on other organs Y/N

Answer 5

Y

Question 6

raloxifene can improve menopause sx Y/N

Answer 6

N

Question 7

fezolinetant (MOA)

Answer 7

acts on the thermoregulatory centre

Question 8

HRT can replace contraceptive pill Y/N

Answer 8

N

Question 9

Contraindication of using HRT

Answer 9

age > 60
estrogen-dependent cancer (endomaterial / breast cancer)
liver disease
vginal bleeding which has not be investigated
High VTE risk / previous hx of MI
uncontrolled high BP

Question 10

Benefit of combine (E+P) HTR

Answer 10

reuduce the risk of fracture (bone density)
reduce the risk of diabete (unknown reason)
reduce the sx like vasomotor
reduce colorectal cancer risk

Question 11

Risk of combine (E+P) HTR

Answer 11

increase the risk of VTE/ stroke
increase the risk of invasive breast cancer
increase the risk of dementia
cornonary heart disease
gall bladder disease
urinary incontinence

Question 12

whithdraw slowly Y/N

Answer 12

Y

Question 13

compared to combine HRT, estrogen only therapy does not increase the risk of

Answer 13

cornonary heart disease
dementia
invasive breast cancer