Osteoarthritis Flashcards
hyaline cartilage normally
high H20 content, stiffness
hylane cartilage function
shock absorber of joints
early changes in osteoarthritis
increase in h20 content–>more pliable –>excessive deformation
later changes in osteoarthritis
clefts on hylaine cartilage
chrondrocytes clumb
fibrilation
fibrillation leads to
bone on bone action
bony changes
osteophyte formation- bone spurs
subchondtral sclerosis- bone becomes thicker to absorb more shock
other changes later in bone
inflam infiltrates in synovium
lax ligaments
weak periartuclar muscles because use jts less
main joint affected
knee (medial >patello-femoral>lateral)
medial causes
bown legg knees-varus
hands are affected
DIP>thumb base>PIP
Heberden’s nodes
DIP
Bouchard’s nodes
PIP
inflammatory/erosive OA
bone erosions visible on XR
Oligoarticular/mono-articular
occurs without cause
three types primary osteoarthritis
generalized
spine
oligocarticular/
key causes secondary OA
inflam joint disease
endocrinopathies
metabolic disease
symmetrical secondary OA
inflam hemochromatosis calcium pyrophosphate disease acromegaly wilsons ochronosis
monoarticular secondary oa
avascular necrosis
congenital problems
traum
10 lbs weight gain=
30-60 lbs of force
injuries predispoising to OA
congenital dysplasias
fractures through articular surfaces
ligament or mensical injuries or dislocations
moderate regular running ..
has a low or no risk of OA if you have a normal knee
average lifespan of prostethic knee
15-20 years
tx
nonpharm & joint replacement CHANGE disease
these mask symptoms
nsaids, chondroitin, corisone, tramadol, viscosupplementation (hyaluronate injection maybs), arthoscopic surgery
Tanezumab
treatment group more joint replacement
–less nerves, so dont feel pain so not safe
adult chondrocytes respond to___and do___
hypoxia
increase inflam/cytokines–>increase matrix degradation–>subchondral plate–>calcification–>more microcracks
