Osteoarthritis

Question 0

hyaline cartilage normally

Answer 0

high H20 content, stiffness

Question 1

hylane cartilage function

Answer 1

shock absorber of joints

Question 2

early changes in osteoarthritis

Answer 2

increase in h20 content–>more pliable –>excessive deformation

Question 3

later changes in osteoarthritis

Answer 3

clefts on hylaine cartilage
chrondrocytes clumb
fibrilation

Question 4

fibrillation leads to

Answer 4

bone on bone action

Question 5

bony changes

Answer 5

osteophyte formation- bone spurs

subchondtral sclerosis- bone becomes thicker to absorb more shock

Question 6

other changes later in bone

Answer 6

inflam infiltrates in synovium
lax ligaments
weak periartuclar muscles because use jts less

Question 7

main joint affected

Answer 7

knee (medial >patello-femoral>lateral)

Question 8

medial causes

Answer 8

bown legg knees-varus

Question 9

hands are affected

Answer 9

DIP>thumb base>PIP

Question 10

Heberden’s nodes

Answer 10

DIP

Question 11

Bouchard’s nodes

Answer 11

PIP

Question 12

inflammatory/erosive OA

Answer 12

bone erosions visible on XR

Question 13

Oligoarticular/mono-articular

Answer 13

occurs without cause

Question 14

three types primary osteoarthritis

Answer 14

generalized
spine
oligocarticular/

Question 15

key causes secondary OA

Answer 15

inflam joint disease
endocrinopathies
metabolic disease

Question 16

symmetrical secondary OA

Answer 16

inflam
hemochromatosis
calcium pyrophosphate disease
acromegaly
wilsons
ochronosis

Question 17

monoarticular secondary oa

Answer 17

avascular necrosis
congenital problems
traum

Question 18

10 lbs weight gain=

Answer 18

30-60 lbs of force

Question 19

injuries predispoising to OA

Answer 19

congenital dysplasias
fractures through articular surfaces
ligament or mensical injuries or dislocations

Question 20

moderate regular running ..

Answer 20

has a low or no risk of OA if you have a normal knee

Question 21

average lifespan of prostethic knee

Answer 21

15-20 years

Question 22

tx

Answer 22

nonpharm & joint replacement CHANGE disease
these mask symptoms
nsaids, chondroitin, corisone, tramadol, viscosupplementation (hyaluronate injection maybs), arthoscopic surgery

Question 23

Tanezumab

Answer 23

treatment group more joint replacement

–less nerves, so dont feel pain so not safe

Question 24

adult chondrocytes respond to___and do___

Answer 24

hypoxia

increase inflam/cytokines–>increase matrix degradation–>subchondral plate–>calcification–>more microcracks