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MS > bone tumors > Flashcards

bone tumors Flashcards

0
Q

permeated lesions

A

motheaten; confluent little holes

fast growing things

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1
Q

sclerotic/geographic margin

A

slow growing lesion so that bone has time to respond to it

–bone thickened around sharp margin

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2
Q

lesion mineralization suggests

A

it contains calcium

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3
Q

with calcium, a dense lesion in the bone shaft may be

A

hard to catch

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4
Q

stipped, flocculent and rings and arches patterns suggest

A

cartilage is mineralizing

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5
Q

periosteium reflects

A

triggers inside and outside the bone that determine speed of growth

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6
Q

slow growing cortical lesion

A

continuous pattern of periosteum around it- forming bump

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7
Q

onion skin pattern in periosteum reflects

A

waxing and waning of growth speed

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8
Q

interrupted pattern reflects

A

fast growth

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9
Q

flocculent

A

calcified cartilage where it shouldnt be

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10
Q

slow growth rate

A

georgraphic margin

solid periosteal rxn

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11
Q

intermediate growth rate

A

ill defined internal margin/moth eaten

shells periosteal rxn

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12
Q

fast growth rate

A

permeative internal margin

lamellar periosteal rxn

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13
Q

Fastest growth rate

A

invisible internal margin

periosteal rxn spiculated invisible

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14
Q

geographic lesions include

A 
cysts
chondroma
fibrous dysplasia
giant cell tumor
chrondrosarcoma
osteomyelitis
metastasis
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15
Q

moth eaten tumors include

A 
osteosarcoma
ewing sarcoma
chondrosarcoma
osteomyelitis
metastasis
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16
Q

permeative tumors include

A 
osteosarcoma
ewing sarcoma
chondrosarcoma
osteomyelitis
metastatsis
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17
Q

tumors of the diaphysis

A 
ewing sarcoma (middle)
osteoid osteoma (edge)
fibrous dysplasia (middle small)
chondromyloid fibroma( edge with metaphysis)
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18
Q

tumors of metaphysis

A 
cysts (middle)
osteochondroma (sticking off side)
osteosa (large middle) 
non-ossifying fibroma (side)
cartilage neoplasms (middle)
giant cell tumor (edge + epiphysis)
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19
Q

epiphysis tumors

A

chrondroblastoma

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20
Q

what tumor is not seem in kids

A

chondrosarcoma

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21
Q

what tumor is not seen in metaphysis

A

ewing

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22
Q

what suggests osteomyelitis

A

increase WBC with a swollen finger

23
Q

primary bone lesions are usually

A

signular

24
Q

bone forming tuors (2)

A

osteoid osteoma

osteosarcoma

25
Q

cartilage forming tumors (3)

A

osteochrondroma
chonrome
chrondosarcoma

26
Q

round cell maliginancies

A

ewing’s tumor
lymphoma
multiple myeloma

27
Q

fibrous tumor like conditiosn

A

fibrous dysplasia

28
Q

fibrous dysplasia

A

diaphyseal, intramedullary fusiform lesiosn with a ground glass appearance that can be associated with growth deformities

29
Q

histo of fibrous tumor-like conditions

A

spindle cells in a colalgenous matrix with woven bone

30
Q

clinical releavance of fibrous dysplasia

A

greater in female

usually in children

31
Q

ewing’s sarcoma

A

childhood malig of primitive mononuclear cells, often presents a diagnostic challenge since its pathological presnetation can mimic ALL and metastatic neuroblastoma

32
Q

where in bone is ewing’s

A

meta-diaphyseal permative lesion with prominent periosteal rx

33
Q

clinical path of swing’s

A

age range 5-15 years
presentation with pain
mets to other bones and lung

34
Q

molecular cytogenetics of ewings

A

translocation of chrom 11;22 –>results in fusion protein EWS FLI-1

35
Q

osteosarcoma path

A

metaphyseal, most often about the knee (most active bone growth)
radio appearance depends on histo (osteoblastic vs chondroblastic) and location (intramedullary, cortical, periosteal)

36
Q

clinical age for osteosarcoam

A

10-25 years, more in men

37
Q

clinical presentation osteosarcoma

A

pain–persistant and sometimes welling or pathologic freacture
mets blood and pulm

38
Q

giant cell tumor is

A

benign but aggressive

39
Q

giant cell tumor path

A

metaphyseal lytic lesion ususally appearing after closure of the growth plates and therefore can extend epiphyseally; usually above the knee

40
Q

clinical course of giant cell tumor

A

ages 20-40 years

may present with pain, pathologic fracture, and recurrence rate is high if primary surgical treatment is inadequate

41
Q

chrondosarcoma is

A

malginant

42
Q

chrondosarcoma can be both

A

intramedullary or peripheral

43
Q

clinical path of chrondrosarcoma

A

adults, usually >50
slwolwy enlarging
sometimes painful–can become quite large, particularly when they arise in pelvic bones

44
Q

osteomyelitis

A

sweollen and painful arm

45
Q

staph osteomylitis shows

A

empty trabeculae (dead osteoblasts)

46
Q

tx of osteomyelitis

A

w/ IV abx

47
Q

benign endochondroma

A

varaibale radiographic appearance depdenent on size, location of bone, degree of calc

lytic with speckled calcification- usually solitary although multiple forms are seen and represent rare clinical syndromes

48
Q

Ollier’s

A

> 1 chrondroma with fibrous displasia (in ref to endochondromas)

49
Q

Maffuci’s

A

> 1 chondroma with angiomata (in ref to endochondroma)

50
Q

clinical present wtih benign endochondroma

A

variable presentations –most common being that of an incidental radiographic finding

51
Q

osteoid osteoma is

A

benign

52
Q

osteoid osteoma path

A

diaphyseal

usually cortical in location with sclertoci thickening within which a small lucent nidus is found

53
Q

nidus is composed of

A

rich vascularized disorganized woven bone and osteoid

54
Q

clinical presenation of osteoid osteoma

A

adolescents (3:1 male:F)
50% femur
pain, progressive severity, often at night

55
Q

how is osteoid osteoma relieved

A

with aspirin

MS (19 decks)

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